Linked Life Data

15883643

Source:http://linkedlifedata.com/resource/pubmed/id/15883643

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-5-10
pubmed:abstractText
The intracellular signaling pathways controlling chondrocyte physiology are largely unknown. Here we show that the small GTPases, Rac1 and Cdc42, accelerate the rate of chondrocyte differentiation and apoptosis, thereby antagonizing the activity of RhoA. These results identify Rac1 and Cdc42 pathways as novel regulators of cartilage development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0884-0431
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1022-31
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15883643-Actins, pubmed-meshheading:15883643-Alkaline Phosphatase, pubmed-meshheading:15883643-Animals, pubmed-meshheading:15883643-Apoptosis, pubmed-meshheading:15883643-Blotting, Western, pubmed-meshheading:15883643-Cell Differentiation, pubmed-meshheading:15883643-Cell Line, pubmed-meshheading:15883643-Cell Proliferation, pubmed-meshheading:15883643-Chondrocytes, pubmed-meshheading:15883643-Collagen Type X, pubmed-meshheading:15883643-DNA, Complementary, pubmed-meshheading:15883643-Enzyme Activation, pubmed-meshheading:15883643-Hypertrophy, pubmed-meshheading:15883643-In Situ Nick-End Labeling, pubmed-meshheading:15883643-Luciferases, pubmed-meshheading:15883643-Mice, pubmed-meshheading:15883643-Promoter Regions, Genetic, pubmed-meshheading:15883643-RNA, pubmed-meshheading:15883643-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15883643-Signal Transduction, pubmed-meshheading:15883643-Transfection, pubmed-meshheading:15883643-cdc42 GTP-Binding Protein, pubmed-meshheading:15883643-p38 Mitogen-Activated Protein Kinases, pubmed-meshheading:15883643-rac1 GTP-Binding Protein, pubmed-meshheading:15883643-rhoA GTP-Binding Protein
pubmed:year
2005
pubmed:articleTitle
Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis.
pubmed:affiliation
CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't