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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2005-5-17
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pubmed:abstractText |
Decay-accelerating factor (Daf) dissociates C3/C5 convertases that assemble on host cells and thereby prevents complement activation on their surfaces. We demonstrate that during primary T cell activation, the absence of Daf on antigen-presenting cells (APCs) and on T cells enhances T cell proliferation and augments the induced frequency of effector cells. The effect is factor D- and, at least in part, C5-dependent, indicating that local alternative pathway activation is essential. We show that cognate T cell-APC interactions are accompanied by rapid production of alternative pathway components and down-regulation of Daf expression. The findings argue that local alternative pathway activation and surface Daf protein function respectively as a costimulator and a negative modulator of T cell immunity and explain previously reported observations linking complement to T cell function. The results could have broad therapeutic implications for disorders in which T cell immunity is important.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-10431155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-10535984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-10881175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-11067947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-11200070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-11683962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-11927943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-12001996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-12042808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-12081998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-12421964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-12496404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-12517942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-1370460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-14688331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-14707087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-15084163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-15286806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-15294968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-2459203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-2973431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-6238120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-8621057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-8898942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-9064337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-9143681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15883171-9885914
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1523-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15883171-Animals,
pubmed-meshheading:15883171-Antigens, CD55,
pubmed-meshheading:15883171-Cell Communication,
pubmed-meshheading:15883171-Cell Proliferation,
pubmed-meshheading:15883171-Complement C3-C5 Convertases,
pubmed-meshheading:15883171-Complement System Proteins,
pubmed-meshheading:15883171-Dendritic Cells,
pubmed-meshheading:15883171-Down-Regulation,
pubmed-meshheading:15883171-Enzyme Activation,
pubmed-meshheading:15883171-Female,
pubmed-meshheading:15883171-Immunity, Cellular,
pubmed-meshheading:15883171-Interleukin-6,
pubmed-meshheading:15883171-Leukemia Inhibitory Factor,
pubmed-meshheading:15883171-Lymphocyte Activation,
pubmed-meshheading:15883171-Male,
pubmed-meshheading:15883171-Mice,
pubmed-meshheading:15883171-Mice, Knockout,
pubmed-meshheading:15883171-Signal Transduction,
pubmed-meshheading:15883171-T-Lymphocytes
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pubmed:year |
2005
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pubmed:articleTitle |
Decay-accelerating factor modulates induction of T cell immunity.
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pubmed:affiliation |
Department of Immunology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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