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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-5-10
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pubmed:abstractText |
To avoid the possible confounding effect of population stratification, we employed a discordant sibling study design and a liberalization of the sibling transmission disequilibrium test to confirm the association of the S18Y variant of the ubiquitin carboxi-terminal hydrolase L1 (UCHL1) gene with Parkinson's disease (PD). The study included 497 case-control pairs (427 case-unaffected sibling pairs and 70 case-unrelated control pairs). Analyses confirmed a significant inverse association of the UCHL1 S18Y polymorphism with PD overall (OR=0.18, 95% CI=0.05-0.64, p=0.002, recessive model) and in several strata.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0304-3940
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pubmed:author |
pubmed-author:AhlskogJ EricJE,
pubmed-author:BowerJames HJH,
pubmed-author:CunninghamJulie MJM,
pubmed-author:FacherisMaurizioM,
pubmed-author:FarrerMathew JMJ,
pubmed-author:LesnickTimothy GTG,
pubmed-author:LincolnSarahS,
pubmed-author:MaraganoreDemetrius MDM,
pubmed-author:RoccaWalter AWA,
pubmed-author:StrainKari JKJ,
pubmed-author:de AndradeMarizaM
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pubmed:issnType |
Print
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pubmed:volume |
381
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
131-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15882803-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:15882803-Case-Control Studies,
pubmed-meshheading:15882803-DNA Mutational Analysis,
pubmed-meshheading:15882803-Genetic Predisposition to Disease,
pubmed-meshheading:15882803-Genetic Testing,
pubmed-meshheading:15882803-Incidence,
pubmed-meshheading:15882803-Parkinson Disease,
pubmed-meshheading:15882803-Polymorphism, Genetic,
pubmed-meshheading:15882803-Risk Assessment,
pubmed-meshheading:15882803-Risk Factors,
pubmed-meshheading:15882803-Siblings,
pubmed-meshheading:15882803-Ubiquitin Thiolesterase,
pubmed-meshheading:15882803-United States
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pubmed:articleTitle |
UCHL1 is associated with Parkinson's disease: a case-unaffected sibling and case-unrelated control study.
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pubmed:affiliation |
Department of Neurology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Controlled Clinical Trial,
Research Support, N.I.H., Extramural
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