Linked Life Data

15882787

Source:http://linkedlifedata.com/resource/pubmed/id/15882787

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2005-5-10
pubmed:abstractText
Interstitial cystitis (IC) is a painful disorder which affects urinary bladder function in cats and humans. We have used patch clamp techniques to examine the possibility that the properties of primary afferent neurons are changed in feline interstitial cystitis (FIC). We measured transient receptor potential vanilloid receptor 1 (TRPV1) responses to capsaicin (CAPS) in dorsal root ganglion (DRG) neurons (L4-S3) from normal cats and cats with FIC. We show that FIC neurons are increased in size and exhibit CAPS responses which are increased in amplitude and desensitize slowly. CAPS responses desensitized seven times slower in FIC neurons. Phorbol 12,13-dibutyrate (PDBu), an activator of PKC, slowed the desensitization of CAPS responses in normal cat bladder and non-bladder neurons, but had no effect in FIC neurons. Bisindolylmaleimide, an inhibitor of PKC, reversed the PDBu effects in normal cat neurons and normalized the desensitization of CAPS responses in FIC neurons. Our data suggest that FIC afferent neurons exhibit abnormal CAPS responses. The latter may be due to enhanced endogenous activities of PKC.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-10379728, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-10476717, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-11140687, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-11148669, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-11283319, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-11458068, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-11483711, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-11587715, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-11792956, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-12660348, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-12694383, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-12721338, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-14523239, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-15028097, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-15066994, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-15371816, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-7542136, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-7963269, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-9133377, http://linkedlifedata.com/resource/pubmed/commentcorrection/15882787-9679937
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:volume
381
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
42-6
pubmed:dateRevised
2011-4-25
pubmed:meshHeading
pubmed:articleTitle
Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis.
pubmed:affiliation
Department of Pharmacology, School of Medicine, University of Pittsburgh, 200 Lathrope Street, W1354 Biomedical Science Tower, Pittsburgh, PA 15261, USA. ads5@pitt.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural