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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-5-10
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pubmed:abstractText |
The POU-domain transcription factor Oct-4 is normally expressed in pluripotent cells of the mammalian embryo. In addition, germ-cell tumors and a few somatic tumors show detectable expression of Oct-4. While Oct-4's role during preimplantation development is to maintain embryonic cells in a pluripotent state, little is known about its potential oncogenic properties. Here we investigate the effect of ectopic Oct-4 expression on somatic tissues of adult mice using a doxycycline-dependent expression system. Activation of Oct-4 results in dysplastic growths in epithelial tissues that are dependent on continuous Oct-4 expression. Dysplastic lesions show an expansion of progenitor cells and increased beta-catenin transcriptional activity. In the intestine, Oct-4 expression causes dysplasia by inhibiting cellular differentiation in a manner similar to that in embryonic cells. These data show that certain adult progenitors remain competent to interpret key embryonic signals and support the notion that progenitor cells are a driving force in tumorigenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Doxycycline,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Octamer Transcription Factor-3,
http://linkedlifedata.com/resource/pubmed/chemical/Pou5f1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
121
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
465-77
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15882627-Animals,
pubmed-meshheading:15882627-Cell Differentiation,
pubmed-meshheading:15882627-Cell Lineage,
pubmed-meshheading:15882627-Cytoskeletal Proteins,
pubmed-meshheading:15882627-DNA-Binding Proteins,
pubmed-meshheading:15882627-Doxycycline,
pubmed-meshheading:15882627-Epithelium,
pubmed-meshheading:15882627-Gastrointestinal Tract,
pubmed-meshheading:15882627-Gene Expression,
pubmed-meshheading:15882627-Green Fluorescent Proteins,
pubmed-meshheading:15882627-Intestines,
pubmed-meshheading:15882627-Mice,
pubmed-meshheading:15882627-Mice, Transgenic,
pubmed-meshheading:15882627-Neoplasms,
pubmed-meshheading:15882627-Octamer Transcription Factor-3,
pubmed-meshheading:15882627-Skin,
pubmed-meshheading:15882627-Stem Cells,
pubmed-meshheading:15882627-Trans-Activators,
pubmed-meshheading:15882627-Transcription Factors,
pubmed-meshheading:15882627-beta Catenin
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pubmed:year |
2005
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pubmed:articleTitle |
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues.
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pubmed:affiliation |
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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