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rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0007613,
umls-concept:C0007634,
umls-concept:C0017296,
umls-concept:C0018270,
umls-concept:C0030281,
umls-concept:C0034963,
umls-concept:C0085243,
umls-concept:C0205263,
umls-concept:C0205373,
umls-concept:C0220905,
umls-concept:C1416467,
umls-concept:C1510411
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pubmed:issue |
9
|
|
pubmed:dateCreated |
2005-5-9
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|
pubmed:abstractText |
Type 1 diabetes results from auto-aggressive T-cell-mediated destruction of beta cells of the pancreas. Recent data suggest that restoration of self-tolerance may facilitate islet-cell regeneration/recovery. In view of the immunoregulatory activity of transforming growth factor (TGF)-beta1, we investigated whether systemic TGF-beta1 gene therapy blocks islet destructive autoimmunity and facilitates regeneration of beta-cell function in overtly diabetic nonobese diabetic (NOD) mice.
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pubmed:grant |
|
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0041-1337
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|
pubmed:author |
pubmed-author:CrystalRonald GRG,
pubmed-author:DeBishnu PBP,
pubmed-author:HancockWayne WWW,
pubmed-author:KimIl SooIS,
pubmed-author:LuoXunrongX,
pubmed-author:MuthukumarThangamaniT,
pubmed-author:OzkaynakEnginE,
pubmed-author:Saint-HilaireFluddF,
pubmed-author:SuthanthiranManikkamM,
pubmed-author:ThomasDolca ADA,
pubmed-author:YangHuaH
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
79
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1091-6
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|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:15880049-Animals,
pubmed-meshheading:15880049-DNA-Binding Proteins,
pubmed-meshheading:15880049-Diabetes Mellitus, Type 1,
pubmed-meshheading:15880049-Disease Models, Animal,
pubmed-meshheading:15880049-Extracellular Matrix Proteins,
pubmed-meshheading:15880049-Forkhead Transcription Factors,
pubmed-meshheading:15880049-Gene Therapy,
pubmed-meshheading:15880049-Graft Survival,
pubmed-meshheading:15880049-Humans,
pubmed-meshheading:15880049-Islets of Langerhans,
pubmed-meshheading:15880049-Islets of Langerhans Transplantation,
pubmed-meshheading:15880049-Mice,
pubmed-meshheading:15880049-Mice, Inbred NOD,
pubmed-meshheading:15880049-Mice, Transgenic,
pubmed-meshheading:15880049-Nephrectomy,
pubmed-meshheading:15880049-Regeneration,
pubmed-meshheading:15880049-Transforming Growth Factor beta
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice.
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|
pubmed:affiliation |
Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA.
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|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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