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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-9
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pubmed:abstractText |
Pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to play an important role in the regulation of islet function. We investigated its effects in beta-cell-specific calmodulin-overexpressing diabetic (CaMTg) mice, in which we consider that apoptosis of beta cells is the primary defect leading to basal hyperglycaemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0804-4643
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
152
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
805-11
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:15879367-Animals,
pubmed-meshheading:15879367-Blood Glucose,
pubmed-meshheading:15879367-Calmodulin,
pubmed-meshheading:15879367-Diabetes Mellitus, Experimental,
pubmed-meshheading:15879367-Gene Expression,
pubmed-meshheading:15879367-Hyperglycemia,
pubmed-meshheading:15879367-Insulin,
pubmed-meshheading:15879367-Islets of Langerhans,
pubmed-meshheading:15879367-Mice,
pubmed-meshheading:15879367-Mice, Inbred ICR,
pubmed-meshheading:15879367-Mice, Transgenic,
pubmed-meshheading:15879367-Nerve Growth Factors,
pubmed-meshheading:15879367-Neuropeptides,
pubmed-meshheading:15879367-Neurotransmitter Agents,
pubmed-meshheading:15879367-Pituitary Adenylate Cyclase-Activating Polypeptide
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pubmed:year |
2005
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pubmed:articleTitle |
Systemic administration of pituitary adenylate cyclase-activating polypeptide maintains beta-cell mass and retards onset of hyperglycaemia in beta-cell-specific calmodulin-overexpressing transgenic mice.
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pubmed:affiliation |
Department of Endocrinology and Diabetology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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