| pubmed-article:15879097 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15879097 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15879097 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15879097 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:15879097 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15879097 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:15879097 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:15879097 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:15879097 | pubmed:dateCreated | 2005-5-9 | lld:pubmed |
| pubmed-article:15879097 | pubmed:abstractText | Transfer of naive CD4 T cells into lymphopenic mice initiates a proliferative response of the transferred cells, often referred to as homeostatic proliferation. Careful analysis reveals that some of the transferred cells proliferate rapidly and undergo robust differentiation to memory cells, a process we have designated spontaneous proliferation, and other cells proliferate relatively slowly and show more limited evidence of differentiation. In this study we report that spontaneous proliferation is IL-7 independent, whereas the slow proliferation (referred to as homeostatic proliferation) is IL-7 dependent. Administration of IL-7 induces homeostatic proliferation of naive CD4 T cells even within wild-type recipients. Moreover, the activation/differentiation pattern of the two responses are clearly distinguishable, indicating that different activation mechanisms may be involved. Our results reveal the complexity and heterogeneity of lymphopenia-driven T cell proliferation and suggest that they may have fundamentally distinct roles in the maintenance of CD4 T cell homeostasis. | lld:pubmed |
| pubmed-article:15879097 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15879097 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879097 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15879097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15879097 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15879097 | pubmed:month | May | lld:pubmed |
| pubmed-article:15879097 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15879097 | pubmed:author | pubmed-author:PaulWilliam... | lld:pubmed |
| pubmed-article:15879097 | pubmed:author | pubmed-author:MinBookiB | lld:pubmed |
| pubmed-article:15879097 | pubmed:author | pubmed-author:Hu-LiJaneJ | lld:pubmed |
| pubmed-article:15879097 | pubmed:author | pubmed-author:YamaneHidehir... | lld:pubmed |
| pubmed-article:15879097 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15879097 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15879097 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:15879097 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15879097 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15879097 | pubmed:pagination | 6039-44 | lld:pubmed |
| pubmed-article:15879097 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:meshHeading | pubmed-meshheading:15879097... | lld:pubmed |
| pubmed-article:15879097 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15879097 | pubmed:articleTitle | Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. | lld:pubmed |
| pubmed-article:15879097 | pubmed:affiliation | Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. minb@ccf.org | lld:pubmed |
| pubmed-article:15879097 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15879097 | pubmed:publicationType | Comparative Study | lld:pubmed |
| entrez-gene:12504 | entrezgene:pubmed | pubmed-article:15879097 | lld:entrezgene |
| entrez-gene:16197 | entrezgene:pubmed | pubmed-article:15879097 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15879097 | lld:pubmed |
