|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2005-5-9
|
|
pubmed:abstractText |
Transfer of naive CD4 T cells into lymphopenic mice initiates a proliferative response of the transferred cells, often referred to as homeostatic proliferation. Careful analysis reveals that some of the transferred cells proliferate rapidly and undergo robust differentiation to memory cells, a process we have designated spontaneous proliferation, and other cells proliferate relatively slowly and show more limited evidence of differentiation. In this study we report that spontaneous proliferation is IL-7 independent, whereas the slow proliferation (referred to as homeostatic proliferation) is IL-7 dependent. Administration of IL-7 induces homeostatic proliferation of naive CD4 T cells even within wild-type recipients. Moreover, the activation/differentiation pattern of the two responses are clearly distinguishable, indicating that different activation mechanisms may be involved. Our results reveal the complexity and heterogeneity of lymphopenia-driven T cell proliferation and suggest that they may have fundamentally distinct roles in the maintenance of CD4 T cell homeostasis.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
174
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6039-44
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15879097-Adoptive Transfer,
pubmed-meshheading:15879097-Animals,
pubmed-meshheading:15879097-CD4-Positive T-Lymphocytes,
pubmed-meshheading:15879097-Cell Differentiation,
pubmed-meshheading:15879097-Cell Division,
pubmed-meshheading:15879097-Cell Proliferation,
pubmed-meshheading:15879097-DNA-Binding Proteins,
pubmed-meshheading:15879097-Homeostasis,
pubmed-meshheading:15879097-Infusion Pumps, Implantable,
pubmed-meshheading:15879097-Interleukin-7,
pubmed-meshheading:15879097-Lymphocyte Activation,
pubmed-meshheading:15879097-Lymphopenia,
pubmed-meshheading:15879097-Mice,
pubmed-meshheading:15879097-Mice, Inbred A,
pubmed-meshheading:15879097-Mice, Inbred C57BL,
pubmed-meshheading:15879097-Mice, Knockout,
pubmed-meshheading:15879097-Mice, Transgenic,
pubmed-meshheading:15879097-Receptors, Antigen, T-Cell,
pubmed-meshheading:15879097-Recombinant Proteins
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms.
|
|
pubmed:affiliation |
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. minb@ccf.org
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
