| pubmed-article:15877933 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15877933 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15877933 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15877933 | lifeskim:mentions | umls-concept:C0016733 | lld:lifeskim |
| pubmed-article:15877933 | lifeskim:mentions | umls-concept:C0021493 | lld:lifeskim |
| pubmed-article:15877933 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:15877933 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:15877933 | lifeskim:mentions | umls-concept:C0813872 | lld:lifeskim |
| pubmed-article:15877933 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15877933 | pubmed:dateCreated | 2005-10-5 | lld:pubmed |
| pubmed-article:15877933 | pubmed:abstractText | GSK-3beta is regarded as playing an important part in the pathogenesis of schizophrenia and the action of psychotomimetic agents. We observed phosphorylation of molecules associated with the GSK-3beta signalling pathway in the rat brain after MK-801 injection, which induces a schizophrenia-like state in humans. Ser9-GSK-3beta phosphorylation was increased after injection of 1 mg/kg MK-801 in the rat frontal cortex but not in the hippocampus or cerebellum. This increase peaked at 30 min and was maintained until 90 min after injection. The phosphorylation showed a dose-dependent increase up to 1 mg/kg MK-801, followed by a decrease at higher dosage. Furthermore, phosphorylation of Ser473-Akt and Ser133-CREB showed similar temporal, dose-dependent and regionally specific patterns with those of Ser9-GSK-3beta. However, phosphorylation of Dvl and Ser33-beta-catenin was not affected by MK-801. These results suggest that GSK-3beta phosphorylation by MK-801 may be associated with the Akt-GSK-3beta pathway rather than with the Wnt-Dvl-GSK3beta pathway. | lld:pubmed |
| pubmed-article:15877933 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15877933 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15877933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15877933 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15877933 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:15877933 | pubmed:issn | 1461-1457 | lld:pubmed |
| pubmed-article:15877933 | pubmed:author | pubmed-author:KimYong SikYS | lld:pubmed |
| pubmed-article:15877933 | pubmed:author | pubmed-author:JuhnnYong-Sun... | lld:pubmed |
| pubmed-article:15877933 | pubmed:author | pubmed-author:AhnYong MinYM | lld:pubmed |
| pubmed-article:15877933 | pubmed:author | pubmed-author:YoonSe... | lld:pubmed |
| pubmed-article:15877933 | pubmed:author | pubmed-author:KimSe HyunSH | lld:pubmed |
| pubmed-article:15877933 | pubmed:author | pubmed-author:SeoMyoung... | lld:pubmed |
| pubmed-article:15877933 | pubmed:author | pubmed-author:KimYeniY | lld:pubmed |
| pubmed-article:15877933 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15877933 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:15877933 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15877933 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15877933 | pubmed:pagination | 607-13 | lld:pubmed |
| pubmed-article:15877933 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:meshHeading | pubmed-meshheading:15877933... | lld:pubmed |
| pubmed-article:15877933 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15877933 | pubmed:articleTitle | Increased phosphorylation of Ser473-Akt, Ser9-GSK-3beta and Ser133-CREB in the rat frontal cortex after MK-801 intraperitoneal injection. | lld:pubmed |
| pubmed-article:15877933 | pubmed:affiliation | Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-799, Korea. | lld:pubmed |
| pubmed-article:15877933 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15877933 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15877933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15877933 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15877933 | lld:pubmed |
