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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-10-5
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pubmed:abstractText |
GSK-3beta is regarded as playing an important part in the pathogenesis of schizophrenia and the action of psychotomimetic agents. We observed phosphorylation of molecules associated with the GSK-3beta signalling pathway in the rat brain after MK-801 injection, which induces a schizophrenia-like state in humans. Ser9-GSK-3beta phosphorylation was increased after injection of 1 mg/kg MK-801 in the rat frontal cortex but not in the hippocampus or cerebellum. This increase peaked at 30 min and was maintained until 90 min after injection. The phosphorylation showed a dose-dependent increase up to 1 mg/kg MK-801, followed by a decrease at higher dosage. Furthermore, phosphorylation of Ser473-Akt and Ser133-CREB showed similar temporal, dose-dependent and regionally specific patterns with those of Ser9-GSK-3beta. However, phosphorylation of Dvl and Ser33-beta-catenin was not affected by MK-801. These results suggest that GSK-3beta phosphorylation by MK-801 may be associated with the Akt-GSK-3beta pathway rather than with the Wnt-Dvl-GSK3beta pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1461-1457
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
607-13
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:15877933-Actins,
pubmed-meshheading:15877933-Animals,
pubmed-meshheading:15877933-Blotting, Western,
pubmed-meshheading:15877933-Catenins,
pubmed-meshheading:15877933-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:15877933-Dizocilpine Maleate,
pubmed-meshheading:15877933-Dose-Response Relationship, Drug,
pubmed-meshheading:15877933-Excitatory Amino Acid Antagonists,
pubmed-meshheading:15877933-Glycogen Synthase Kinase 3,
pubmed-meshheading:15877933-Injections, Intraperitoneal,
pubmed-meshheading:15877933-Male,
pubmed-meshheading:15877933-Phosphorylation,
pubmed-meshheading:15877933-Prefrontal Cortex,
pubmed-meshheading:15877933-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:15877933-Rats,
pubmed-meshheading:15877933-Rats, Sprague-Dawley,
pubmed-meshheading:15877933-Serine
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pubmed:year |
2005
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pubmed:articleTitle |
Increased phosphorylation of Ser473-Akt, Ser9-GSK-3beta and Ser133-CREB in the rat frontal cortex after MK-801 intraperitoneal injection.
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pubmed:affiliation |
Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-799, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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