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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-6
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pubmed:abstractText |
The recently discovered apolipoprotein A5 ( APOA5 ) gene has been shown to be important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. We searched for possible associations of the APOA5 gene polymorphisms S19W and -1131T>C with coronary heart disease (CHD) in a Chinese population. A total of 483 Chinese CHD patients and 502 control non-CHD subjects were genotyped by polymerase chain reaction-restriction fragment length polymorphism for these 2 single nucleotide polymorphisms. We found that the minor allele 19W was observed only in CHD patients and not in controls, with allelic frequencies of 0.047 and 0.000, respectively ( P < .000001), and the minor allele -1131C was significantly higher in CHD patients than in controls (0.391 vs 0.299, P < .0001). These results suggest that both the S19W and -1131T>C variations in the APOA5 gene are associated with the CHD and appear to be 2 genetic risk factors for CHD susceptibility in Chinese. Moreover, we found that triglyceride levels were significantly higher in -1131C carriers than in -1131T subjects of the control group and that high-density-lipoprotein cholesterol was decreased in -1131C carriers among CHD patients.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/APOA5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins A,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cytosine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Thymine,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Tryptophan
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0026-0495
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pubmed:author |
pubmed-author:CarrascoA BAB,
pubmed-author:GILGG,
pubmed-author:HuangAiminA,
pubmed-author:HuangDejiaD,
pubmed-author:LiGuixinG,
pubmed-author:LiXuefeiX,
pubmed-author:LinJianyinJ,
pubmed-author:NebertDaniel WDW,
pubmed-author:ShiJiajunJ,
pubmed-author:SuZhiguangZ,
pubmed-author:WangChuntingC,
pubmed-author:XiaoCuiyingC,
pubmed-author:ZhangSizhongS,
pubmed-author:ZhengKeqinK,
pubmed-author:ZhouBingB
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
568-72
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15877284-Apolipoproteins,
pubmed-meshheading:15877284-Apolipoproteins A,
pubmed-meshheading:15877284-Asian Continental Ancestry Group,
pubmed-meshheading:15877284-Case-Control Studies,
pubmed-meshheading:15877284-Cholesterol, HDL,
pubmed-meshheading:15877284-Coronary Disease,
pubmed-meshheading:15877284-Cytosine,
pubmed-meshheading:15877284-DNA,
pubmed-meshheading:15877284-Fasting,
pubmed-meshheading:15877284-Female,
pubmed-meshheading:15877284-Genetic Variation,
pubmed-meshheading:15877284-Heterozygote,
pubmed-meshheading:15877284-Humans,
pubmed-meshheading:15877284-Male,
pubmed-meshheading:15877284-Middle Aged,
pubmed-meshheading:15877284-Polymorphism, Single Nucleotide,
pubmed-meshheading:15877284-Serine,
pubmed-meshheading:15877284-Thymine,
pubmed-meshheading:15877284-Triglycerides,
pubmed-meshheading:15877284-Tryptophan
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pubmed:year |
2005
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pubmed:articleTitle |
Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese.
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pubmed:affiliation |
State Key Laboratory of Biotherapy, Division of Human Morbid Genomics, Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu 610041, China.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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