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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2005-6-1
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pubmed:abstractText |
The synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis (RCM) is described. Based on the Ac-Nle-Gly-Lys-D-Phe-Arg-Trp-Gly-NH2-MC4 ligand, Ac-Nle-Alg-Lys-D-Phe-Arg-Trp-Alg-NH2 was designed and synthesized followed by cyclization using RCM. Both compounds are high affinity and selective MC4-R-agonists. The cyclic RCM-peptide was more potent in a rat-grooming assay.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4221-7
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:15876540-Animals,
pubmed-meshheading:15876540-Cells, Cultured,
pubmed-meshheading:15876540-Cyclization,
pubmed-meshheading:15876540-Humans,
pubmed-meshheading:15876540-Kidney,
pubmed-meshheading:15876540-Ligands,
pubmed-meshheading:15876540-Melanocyte-Stimulating Hormones,
pubmed-meshheading:15876540-Peptides, Cyclic,
pubmed-meshheading:15876540-Rats,
pubmed-meshheading:15876540-Receptor, Melanocortin, Type 4,
pubmed-meshheading:15876540-Structure-Activity Relationship
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pubmed:year |
2005
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pubmed:articleTitle |
Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis.
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pubmed:affiliation |
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article
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