|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004927,
umls-concept:C0009010,
umls-concept:C0038435,
umls-concept:C0038585,
umls-concept:C0041390,
umls-concept:C0205191,
umls-concept:C0231491,
umls-concept:C0521425,
umls-concept:C0542298,
umls-concept:C0549193,
umls-concept:C0597357,
umls-concept:C1280500,
umls-concept:C1424685,
umls-concept:C1555903
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2005-10-25
|
|
pubmed:abstractText |
Substance P and its preferred receptor, the neurokinin 1 receptor (NK(1)R), have been proposed as possible targets for new antidepressant therapies, although results of a recently completed phase III trial failed to demonstrate that the NK(1)R antagonist MK-869 is more effective than placebo in the treatment of depression.
|
|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0033-3158
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
181
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
207-16
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15875166-Adrenal Glands,
pubmed-meshheading:15875166-Animals,
pubmed-meshheading:15875166-Behavior, Animal,
pubmed-meshheading:15875166-Clomipramine,
pubmed-meshheading:15875166-Endocrine System,
pubmed-meshheading:15875166-Epididymis,
pubmed-meshheading:15875166-Grooming,
pubmed-meshheading:15875166-Hydrocortisone,
pubmed-meshheading:15875166-Hypothalamo-Hypophyseal System,
pubmed-meshheading:15875166-Male,
pubmed-meshheading:15875166-Morpholines,
pubmed-meshheading:15875166-Motor Activity,
pubmed-meshheading:15875166-Norepinephrine,
pubmed-meshheading:15875166-Organ Size,
pubmed-meshheading:15875166-Receptors, Neurokinin-1,
pubmed-meshheading:15875166-Stress, Psychological,
pubmed-meshheading:15875166-Substance P,
pubmed-meshheading:15875166-Sympathetic Nervous System,
pubmed-meshheading:15875166-Tupaiidae
|
|
pubmed:year |
2005
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|
pubmed:articleTitle |
Chronic psychosocial stress in tree shrews: effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters.
|
|
pubmed:affiliation |
Clinical Neurobiology Laboratory, German Primate Center, Göttingen. m.g.c.van.der.hart@psy.umcg.nl
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
