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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-5
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pubmed:abstractText |
The genetic and antigenic variability of human respiratory syncytial virus (HRSV) strains isolated in Buenos Aires from 1995 to 2001 was evaluated by partial nucleotide sequencing of the G gene and enzyme-linked immunosorbent assay analysis with anti-G monoclonal antibodies. Phylogenetic analyses showed that 37 group A strains clustered into five genotypes, whereas 20 group B strains clustered into three genotypes. Group A showed more genetic variability than group B. A close correlation between genotypes and antigenic patterns was observed. Changes detected in the G protein of viruses from both groups included (i) amino acid substitutions and(ii) differences in protein length due to either changes in stop codon usage or sequence duplications. Three B strains from 1999 exhibited a duplication of 20 amino acids, while one B strain from 2001 had 2 amino acids duplicated. The comparison among Argentinean HRSV strains and viruses isolated in other geographical areas during different epidemics is discussed.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0095-1137
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2266-73
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15872254-Amino Acid Sequence,
pubmed-meshheading:15872254-Antigens, Viral,
pubmed-meshheading:15872254-Argentina,
pubmed-meshheading:15872254-Base Sequence,
pubmed-meshheading:15872254-Cell Line, Tumor,
pubmed-meshheading:15872254-Child, Preschool,
pubmed-meshheading:15872254-DNA Primers,
pubmed-meshheading:15872254-Humans,
pubmed-meshheading:15872254-Molecular Sequence Data,
pubmed-meshheading:15872254-Phylogeny,
pubmed-meshheading:15872254-RNA, Viral,
pubmed-meshheading:15872254-Respiratory Syncytial Virus, Human,
pubmed-meshheading:15872254-Respiratory Syncytial Virus Infections,
pubmed-meshheading:15872254-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2005
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pubmed:articleTitle |
Genetic and antigenic variability of human respiratory syncytial virus (groups a and b) isolated over seven consecutive seasons in Argentina (1995 to 2001).
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pubmed:affiliation |
Laboratorio de Virología Clínica, Centro de Educacion Médica e Investigaciones Clínicas, CEMIC, Hospiatal Universitario, Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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