Linked Life Data

15872076

Source:http://linkedlifedata.com/resource/pubmed/id/15872076

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2005-6-29
pubmed:abstractText
Impaired renal function and albuminuria, common among people with type 2 diabetes, are strong predictors of atherosclerotic cardiovascular events. However, the relationships among albuminuria and measures of calcified atherosclerotic plaque are unknown. Coronary and carotid artery calcified plaque were measured using fast-gated helical computed tomography, and B-mode ultrasonography measured common carotid artery intima-medial thickness (IMT) in 588 white participants with type 2 diabetes from 325 families ascertained for the presence of multiple siblings with type 2 diabetes. Measured risk factors included age, gender, BP, body mass index, GFR, glycosylated hemoglobin, LDL cholesterol, HDL cholesterol, smoking, and medications that affect urine albumin:creatinine ratio (ACR). Generalized estimating equations with exchangeable correlation and the sandwich estimator of the variance were used to test for an association among coronary artery calcified plaque, carotid artery calcified plaque, carotid IMT, and ACR while adjusting for measured risk factors. Participants had a mean +/- SD (median) age of 61.2 +/- 9.2 yr (61.0 yr), ACR of 106.2 +/- 590 mg/g (12.9 mg/g), GFR of 93.3 +/- 33.2 ml/min (87.4 ml/min), coronary artery calcium mass score of 1394 +/- 2685 (323), carotid artery calcium mass score of 295 +/- 652 (51), and IMT of 0.66 +/- 0.12 mm (0.65 mm). Adjusting for the measured covariates, ACR was strongly and positively associated with coronary artery calcium (P = 0.004) and carotid artery calcium (P = 0.0004). Albuminuria is strongly associated with calcified plaque in the coronary and carotid arteries in white individuals with type 2 diabetes and relatively preserved renal function.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1046-6673
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2156-61
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Relationship between albuminuria and cardiovascular disease in Type 2 diabetes.
pubmed:affiliation
Department of Internal Medicine/Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, USA. bfreedma@wfubmc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural