| pubmed-article:15870944 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C0319852 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C1326205 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C2828366 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C1705851 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C0599956 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C1555707 | lld:lifeskim |
| pubmed-article:15870944 | lifeskim:mentions | umls-concept:C2752151 | lld:lifeskim |
| pubmed-article:15870944 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15870944 | pubmed:dateCreated | 2005-5-4 | lld:pubmed |
| pubmed-article:15870944 | pubmed:abstractText | Cordyceps militaris is a traditional herbal ingredient, which has been used for patients suffering from cancer in Oriental medicine. In the present study, we investigated the biochemical mechanisms of anti-proliferative effects by aqueous extract of C. militaris (AECM) in human leukemia U937 cells. It was found that AECM could inhibit cell growth of U937 cells in a dose-dependent manner, which was associated with morphological change and apoptotic cell death such as formation of apoptotic bodies and DNA fragmentation. We observed the down-regulation of anti-apoptotic Bcl-2 expression and proteolytic activation of caspase-3 in AECM-treated U937 cells. However, AECM did not affect the pro-apoptotic Bax expression and activity of caspase-9. Furthermore, Western blotting and RT-PCR revealed that AECM treatment caused a dose-dependent inhibition of cyclooxygenase-2 and prostaglandin E2 accumulation. Taken together, these results indicated that the anti-proliferative effects of AECM were associated with the induction of apoptotic cell death through regulation of several major growth regulatory gene products such as Bcl-2 family expression and caspase protease activity, and AECM may have therapeutic potential in human leukemia treatment. | lld:pubmed |
| pubmed-article:15870944 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15870944 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15870944 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15870944 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15870944 | pubmed:issn | 1021-335X | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:ChoiYung... | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:ParkDong IlDI | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:ChoiByung... | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:KimGi-YoungGY | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:ParkYeong-Min... | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:JeongYong-Kee... | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:LeeJae-YunJY | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:ParkCheolC | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:HongSang... | lld:pubmed |
| pubmed-article:15870944 | pubmed:author | pubmed-author:LeeYong TeaYT | lld:pubmed |
| pubmed-article:15870944 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15870944 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:15870944 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15870944 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15870944 | pubmed:pagination | 1211-6 | lld:pubmed |
| pubmed-article:15870944 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:meshHeading | pubmed-meshheading:15870944... | lld:pubmed |
| pubmed-article:15870944 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15870944 | pubmed:articleTitle | Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis. | lld:pubmed |
| pubmed-article:15870944 | pubmed:affiliation | Department of Oriental Medicine, Dongeui University College of Oriental Medicine, Biomedical Research Center of Oriental Medicine, Busan 614-052, Korea. | lld:pubmed |
| pubmed-article:15870944 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15870944 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
