Linked Life Data

15870933

Source:http://linkedlifedata.com/resource/pubmed/id/15870933

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-5-4
pubmed:abstractText
Kelch-like proteins are implicated in embryogenesis and carcinogenesis through cytoskeleton organization. KLHL (kelch homolog) genes, containing two evolutionary conserved domains--broad-complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, and kelch motif, are human homologs of Drosophila kelch gene. We identified the KLHL15 gene, a novel human homolog of Drosophila kelch, by using bioinformatics. KLHL15 gene, consisting of 4 exons, was located within human genome sequences RP11-47911 (AC079169.32) and RP11-793H5 (AC079376.26). Complete coding sequence of human KLHL15 cDNA was determined by assembling FLJ32736 cDNA (AK057298) and KIAA1677 cDNA (AB051464). The human, chicken, and zebra fish KLHL15 (604 aa) showed 85-93% total-amino acid identity. N-terminal BTB/POZ domain and C-terminal three KELCH motifs were identified within KLHL15 protein by using the Pfam program. Human KLHL15 mRNA was expressed ubiquitously in various tissues. This is the first report on identification and characterization of the KLHL15 gene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1021-335X
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1133-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Identification and characterization of a novel kelch-like gene KLHL15 in silico.
pubmed:affiliation
Department of Life Sciences, Meiji University, Kawasaki, Kanagawa 214-8571, Japan. yoshida@isc.meiji.ac.jp
pubmed:publicationType
Journal Article, Comparative Study