15869856

Source:http://linkedlifedata.com/resource/pubmed/id/15869856

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0037628, umls-concept:C0179038, umls-concept:C0360100, umls-concept:C0439831, umls-concept:C0680730, umls-concept:C1148554
pubmed:issue	1-2
pubmed:dateCreated	2005-8-8
pubmed:abstractText	A rapid gravimetric method for determining drug candidate solubility in organic solvents has been developed. The scale, speed, precision, and accuracy of the method make it ideal for solubility screening of pharmaceutical compounds during early development. The method utilizes a thermogravimetric analyzer to automate drying and weighing. Results for model compounds compare favorably with literature values.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8309336
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Organic Chemicals, http://linkedlifedata.com/resource/pubmed/chemical/Solvents
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0731-7085
pubmed:author	pubmed-author:BlackburnAnthony CAC, pubmed-author:GreeneLandon RLR, pubmed-author:MillerJonathan MJM
pubmed:issnType	Print
pubmed:day	1
pubmed:volume	39
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	344-7
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:15869856-Organic Chemicals, pubmed-meshheading:15869856-Reproducibility of Results, pubmed-meshheading:15869856-Solubility, pubmed-meshheading:15869856-Solvents
pubmed:year	2005
pubmed:articleTitle	Rapid, small-scale determination of organic solvent solubility using a thermogravimetric analyzer.
pubmed:affiliation	Pharmaceutical Research and Development, World Wide Pharmaceutical Sciences, Pfizer Global Research and Development-Ann Arbor Laboratories, MI 48105, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't