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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1992-6-23
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pubmed:abstractText |
To investigate the impaired cell surface expression of human major histocompatibility antigen (HLA) in transfected L cells, we examined their intracellular localization by immunocytochemistry. HLA class II molecules produced in transfected L cells were mainly detected in the intracellular vesicles and in the nuclear envelope as granular precipitates. The results suggest that the intracellular transport of the newly synthesized molecules in transfected L cells is impaired at some point along the pathway from the rough endoplasmic reticulum (RER) to the medial-, trans-Golgi apparatus.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0386-7196
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:geneSymbol |
HLA-DR
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1586968-Animals,
pubmed-meshheading:1586968-B-Lymphocytes,
pubmed-meshheading:1586968-HLA-D Antigens,
pubmed-meshheading:1586968-HLA-DR Antigens,
pubmed-meshheading:1586968-Immunohistochemistry,
pubmed-meshheading:1586968-L Cells (Cell Line),
pubmed-meshheading:1586968-Mice,
pubmed-meshheading:1586968-Organelles,
pubmed-meshheading:1586968-Transfection
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pubmed:year |
1992
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pubmed:articleTitle |
Intracellular localization of the HLA class II gene products in transfected mouse L cells.
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pubmed:affiliation |
Department of Transplantation, Tokai University School of Medicine, Isehara, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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