Linked Life Data

15869351

Source:http://linkedlifedata.com/resource/pubmed/id/15869351

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-5-4
pubmed:abstractText
The authors highlight the utility of distribution-analytical techniques in the study of individual differences and clinical disorders. Cognitive deficits associated with attention-deficit/hyperactivity disorder (AD/HD) were examined by using delta-plot analyses of performance data (reaction time and accuracy) obtained through the use of a prototypical conflict task, the Eriksen flanker task. In 20 children with AD/HD (compared with matched control participants), overall performance measures indicated a marginal performance deficit. Delta-plot analyses indicated that performance deficits associated with AD/HD involve response inhibition but not automatic response activation. In a within-subjects titration study, the response inhibition deficit was eliminated by methylphenidate treatment, but these effects were highly dose specific. The beneficial effect of methylphenidate was clarified further after correcting for inter-individual variation in sensitivity to medicine dosage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-843X
pubmed:author
pubmed:copyrightInfo
Copyright 2005 APA, all rights reserved.
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
197-215
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed-meshheading:15869351-Attention, pubmed-meshheading:15869351-Attention Deficit Disorder with Hyperactivity, pubmed-meshheading:15869351-Central Nervous System Stimulants, pubmed-meshheading:15869351-Child, pubmed-meshheading:15869351-Cross-Over Studies, pubmed-meshheading:15869351-Dose-Response Relationship, Drug, pubmed-meshheading:15869351-Drug Administration Schedule, pubmed-meshheading:15869351-Humans, pubmed-meshheading:15869351-Individuality, pubmed-meshheading:15869351-Inhibition (Psychology), pubmed-meshheading:15869351-Male, pubmed-meshheading:15869351-Methylphenidate, pubmed-meshheading:15869351-Models, Statistical, pubmed-meshheading:15869351-Psychomotor Performance, pubmed-meshheading:15869351-Reaction Time, pubmed-meshheading:15869351-Task Performance and Analysis, pubmed-meshheading:15869351-Treatment Outcome
pubmed:year
2005
pubmed:articleTitle
Delta plots in the study of individual differences: new tools reveal response inhibition deficits in AD/Hd that are eliminated by methylphenidate treatment.
pubmed:affiliation
Department of Psychology, University of Amsterdam, Amsterdam, Netherlands. k.r.ridderinkhof@uva.nl
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't