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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-3
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pubmed:abstractText |
Elevated production of prostaglandin E2 (PGE2) plays an important role in the pathogenesis of arthritis. Recently, an inducible microsomal prostaglandin E synthase-1 (mPGES-1) was identified. This enzyme is functionally coupled with cyclooxygenase-2 (COX-2) and converts the COX product PGH2 to PGE2. We analyzed expression of mPGES-1 in human normal and osteoarthritic (OA) cartilage and determined the effect of different inflammatory agonists on the expression of mPGES-1 in OA chondrocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/15-deoxyprostaglandin J2,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Intramolecular Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin D2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/prostaglandin-E synthase
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0315-162X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
887-95
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15868626-Aged,
pubmed-meshheading:15868626-Cartilage, Articular,
pubmed-meshheading:15868626-Cells, Cultured,
pubmed-meshheading:15868626-Chondrocytes,
pubmed-meshheading:15868626-Dinoprostone,
pubmed-meshheading:15868626-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:15868626-Humans,
pubmed-meshheading:15868626-Interleukin-1,
pubmed-meshheading:15868626-Interleukin-17,
pubmed-meshheading:15868626-Intramolecular Oxidoreductases,
pubmed-meshheading:15868626-Microsomes,
pubmed-meshheading:15868626-Middle Aged,
pubmed-meshheading:15868626-Osteoarthritis, Knee,
pubmed-meshheading:15868626-PPAR gamma,
pubmed-meshheading:15868626-Prostaglandin D2,
pubmed-meshheading:15868626-RNA, Messenger,
pubmed-meshheading:15868626-Transcription, Genetic,
pubmed-meshheading:15868626-Tumor Necrosis Factor-alpha
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pubmed:year |
2005
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pubmed:articleTitle |
Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes.
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pubmed:affiliation |
Osteoarthritis Research Unit, Centre hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Québec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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