Linked Life Data

15867309

Source:http://linkedlifedata.com/resource/pubmed/id/15867309

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-5-3
pubmed:abstractText
Natural polyphenolic compounds, including flavonoids, which are synthesized by plants, have repeatedly been linked to multiple health benefits, but specific bioactive compounds or individualized roles have been difficult to interpret or to assign. This limitation has prevented the development of robust dietary recommendations. This paper describes a plant-cell-culture production approach that provides uniform yields of abundant natural mixtures of flavonoids from small molecules to high molecular weight oligomers and polymers. The flavonoids correspond to compounds produced in nature by the same plant genotypes; but, through elicitation tactics, the levels and the profiles of the flavonoid yield can be enhanced, and isolation from cell cultures is more rapid and streamlined than isolation from in vivo plant tissues. Introduction of (14)C sucrose to the cell-culture medium enabled the recovery and the identification of biolabeled flavonoid mixtures, which could be easily tracked in serum of rats after gavage. The biolabeled materials are now being investigated to determine tissue localization, structures of bioactive components, and the interactions between flavonoid components that contribute to bioactive potential.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3166
pubmed:author
pubmed:issnType
Print
pubmed:volume
135
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1231-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Sorting out bioactivity in flavonoid mixtures.
pubmed:affiliation
Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801-7715, USA. imagemal@uiuc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.