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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-5-3
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pubmed:abstractText |
Temozolomide, a DNA methylating agent used to treat melanoma, induces DNA damage, which is repaired by O6-alkylguanine alkyltransferase (ATase) and poly(ADP-ribose) polymerase-1 (PARP-1)-dependent base excision repair. The current study was done to define the effect of temozolomide on DNA integrity and relevant repair enzymes as a prelude to a phase I trial of the combination of temozolomide with a PARP inhibitor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BoddyAlan VAV,
pubmed-author:CalvertA HilaryAH,
pubmed-author:CurtinNicola JNJ,
pubmed-author:HarrisAdrian LAL,
pubmed-author:HicksonIanI,
pubmed-author:JonesChristopherC,
pubmed-author:MargisonGeoffrey PGP,
pubmed-author:McGownGailG,
pubmed-author:McHughPeterP,
pubmed-author:MiddletonMark RMR,
pubmed-author:NewellDavid RDR,
pubmed-author:OlsenAnnaA,
pubmed-author:PlummerE RuthER,
pubmed-author:ThorncroftMaryM,
pubmed-author:WatsonAmanda JAJ
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3402-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15867241-Adult,
pubmed-meshheading:15867241-Aged,
pubmed-meshheading:15867241-Aged, 80 and over,
pubmed-meshheading:15867241-Antineoplastic Agents, Alkylating,
pubmed-meshheading:15867241-Comet Assay,
pubmed-meshheading:15867241-DNA, Neoplasm,
pubmed-meshheading:15867241-DNA Damage,
pubmed-meshheading:15867241-DNA Methylation,
pubmed-meshheading:15867241-DNA Repair,
pubmed-meshheading:15867241-Dacarbazine,
pubmed-meshheading:15867241-Female,
pubmed-meshheading:15867241-Headache,
pubmed-meshheading:15867241-Humans,
pubmed-meshheading:15867241-Lymphocytes,
pubmed-meshheading:15867241-Male,
pubmed-meshheading:15867241-Melanoma,
pubmed-meshheading:15867241-Middle Aged,
pubmed-meshheading:15867241-Neoplasm Metastasis,
pubmed-meshheading:15867241-Neutropenia,
pubmed-meshheading:15867241-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:15867241-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:15867241-Thrombocytopenia,
pubmed-meshheading:15867241-Time Factors,
pubmed-meshheading:15867241-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.
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pubmed:affiliation |
Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom. E.R.Plummer@ncl.ac.uk
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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