|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0205269,
umls-concept:C0205314,
umls-concept:C0205390,
umls-concept:C0243044,
umls-concept:C0675974,
umls-concept:C0675975,
umls-concept:C0679622,
umls-concept:C0877373,
umls-concept:C1999216,
umls-concept:C2603343
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2005-5-3
|
|
pubmed:abstractText |
17-(Allylamino)-17-demethoxygeldanamycin (17AAG), a benzoquinone antibiotic, down-regulates oncoproteins by binding specifically to heat shock protein 90 (HSP90). We did a phase I study of 17AAG to establish the dose-limiting toxicity and maximum tolerated dose and to characterize 17AAG pharmacokinetics and pharmacodynamics.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/17-(allylamino)-17-demethoxygeldanam...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/HSP70 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HSP90 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrocortisone,
http://linkedlifedata.com/resource/pubmed/chemical/Lactams, Macrocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Progesterone,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Rifabutin,
http://linkedlifedata.com/resource/pubmed/chemical/Testosterone
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1078-0432
|
|
pubmed:author |
pubmed-author:AgarwalaSanjiv SSS,
pubmed-author:BelaniChandra PCP,
pubmed-author:BrufskyAdam MAM,
pubmed-author:EgorinMerrill JMJ,
pubmed-author:EisemanJulie LJL,
pubmed-author:IvyS PercySP,
pubmed-author:LanJingJ,
pubmed-author:PotterDouglas MDM,
pubmed-author:RamalingamSakkaraiappanS,
pubmed-author:RamanathanRamesh KRK,
pubmed-author:TrumpDonald LDL,
pubmed-author:TutchkoSusanS,
pubmed-author:WongMichael K KMK,
pubmed-author:ZuhowskiEleanor GEG
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3385-91
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15867239-Adult,
pubmed-meshheading:15867239-Aged,
pubmed-meshheading:15867239-Aged, 80 and over,
pubmed-meshheading:15867239-Area Under Curve,
pubmed-meshheading:15867239-Benzoquinones,
pubmed-meshheading:15867239-Diarrhea,
pubmed-meshheading:15867239-Dose-Response Relationship, Drug,
pubmed-meshheading:15867239-Estradiol,
pubmed-meshheading:15867239-Fatigue,
pubmed-meshheading:15867239-Female,
pubmed-meshheading:15867239-Follicle Stimulating Hormone,
pubmed-meshheading:15867239-HSP70 Heat-Shock Proteins,
pubmed-meshheading:15867239-HSP90 Heat-Shock Proteins,
pubmed-meshheading:15867239-Humans,
pubmed-meshheading:15867239-Hydrocortisone,
pubmed-meshheading:15867239-Lactams, Macrocyclic,
pubmed-meshheading:15867239-Leukocytes, Mononuclear,
pubmed-meshheading:15867239-Leukopenia,
pubmed-meshheading:15867239-Luteinizing Hormone,
pubmed-meshheading:15867239-Male,
pubmed-meshheading:15867239-Middle Aged,
pubmed-meshheading:15867239-Nausea,
pubmed-meshheading:15867239-Neoplasms,
pubmed-meshheading:15867239-Progesterone,
pubmed-meshheading:15867239-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15867239-Rifabutin,
pubmed-meshheading:15867239-Testosterone,
pubmed-meshheading:15867239-Treatment Outcome,
pubmed-meshheading:15867239-Vomiting
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Phase I pharmacokinetic-pharmacodynamic study of 17-(allylamino)-17-demethoxygeldanamycin (17AAG, NSC 330507), a novel inhibitor of heat shock protein 90, in patients with refractory advanced cancers.
|
|
pubmed:affiliation |
Molecular Therapeutics/Drug Discovery Program, Biostatistics Department, Graduate School of Public Health, and Biostatistics Facility, University of Pittsburgh Cancer Institute, PA 15232, USA. ramnathanrk@upmc.edu
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Clinical Trial, Phase I,
Research Support, N.I.H., Extramural
|
