Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2005-5-3
pubmed:abstractText
The differentiation-related gene-1 (Drg1) is a recently identified gene down-regulated in malignancy and a putative suppressor of colorectal cancer metastases. Its expression is associated with improved survival in patients with prostate or breast cancer. Drg1 expression is also associated with resistance to irinotecan therapy in preclinical colorectal cancer models. The clinical evaluation of Drg1 in colorectal cancer has been limited. We performed this study to evaluate the role of Drg1 in a large cohort of patients with metastatic colorectal cancer who were irinotecan naive.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3296-302
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:15867226-Aged, pubmed-meshheading:15867226-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:15867226-Camptothecin, pubmed-meshheading:15867226-Cell Cycle Proteins, pubmed-meshheading:15867226-Colorectal Neoplasms, pubmed-meshheading:15867226-Female, pubmed-meshheading:15867226-Fluorouracil, pubmed-meshheading:15867226-Humans, pubmed-meshheading:15867226-Immunohistochemistry, pubmed-meshheading:15867226-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:15867226-Liver Neoplasms, pubmed-meshheading:15867226-Male, pubmed-meshheading:15867226-Middle Aged, pubmed-meshheading:15867226-Prognosis, pubmed-meshheading:15867226-Randomized Controlled Trials as Topic, pubmed-meshheading:15867226-Survival Analysis, pubmed-meshheading:15867226-Treatment Outcome
pubmed:year
2005
pubmed:articleTitle
Drg1 expression in 131 colorectal liver metastases: correlation with clinical variables and patient outcomes.
pubmed:affiliation
Department of Medicine, Division of Solid Tumor Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural