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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-5-3
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pubmed:abstractText |
The scavenger receptor class B, type I (SR-BI) mediates the cellular selective uptake of cholesteryl esters and other lipids from high-density lipoproteins (HDL) and low-density lipoproteins (LDL). This process, unlike classical receptor-mediated endocytosis, does not result in lipoprotein degradation. Instead, the lipid depleted particles are released into the medium. Here we show that selective lipid uptake mediated by murine SR-BI can be uncoupled from the endocytosis of HDL or LDL particles. We found that blocking selective lipid uptake by incubating cells with the small chemical inhibitors BLT-1 or BLT-4 did not affect endocytosis of HDL. Similarly, blocking endocytosis by hyperosmotic sucrose or K+ depletion did not prevent selective lipid uptake from HDL or LDL. These findings suggest that mSR-BI-mediated selective uptake occurs at the cell surface upon the association of lipoproteins with mSR-BI and does not require endocytosis of HDL or LDL particles.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/(1-(2-methoxy-phenyl)-3-naphthalen-2...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD36,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Scavenger,
http://linkedlifedata.com/resource/pubmed/chemical/SCARB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Scavenger Receptors, Class B,
http://linkedlifedata.com/resource/pubmed/chemical/Sucrose,
http://linkedlifedata.com/resource/pubmed/chemical/Urea
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-3002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
1734
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
44-51
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15866482-Animals,
pubmed-meshheading:15866482-Antigens, CD36,
pubmed-meshheading:15866482-CHO Cells,
pubmed-meshheading:15866482-Cricetinae,
pubmed-meshheading:15866482-Endocytosis,
pubmed-meshheading:15866482-Humans,
pubmed-meshheading:15866482-Lipid Metabolism,
pubmed-meshheading:15866482-Lipoproteins, HDL,
pubmed-meshheading:15866482-Lipoproteins, LDL,
pubmed-meshheading:15866482-Mice,
pubmed-meshheading:15866482-Naphthalenes,
pubmed-meshheading:15866482-Osmotic Pressure,
pubmed-meshheading:15866482-Potassium,
pubmed-meshheading:15866482-Receptors, Immunologic,
pubmed-meshheading:15866482-Receptors, Scavenger,
pubmed-meshheading:15866482-Scavenger Receptors, Class B,
pubmed-meshheading:15866482-Sucrose,
pubmed-meshheading:15866482-Urea
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pubmed:year |
2005
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pubmed:articleTitle |
Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI.
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pubmed:affiliation |
Department of Cell Biology, Harvard Medical School and The CBR Institute for Biomedical Research, 200 Longwood Avenue, Room 134, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, N.I.H., Extramural
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