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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-5-2
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pubmed:abstractText |
Primary open-angle glaucoma (POAG) is a leading cause of blindness. High intraocular pressure (IOP) has been shown to be a key risk factor for POAG. Topical application of angiotensin 1-converting enzyme (ACE) inhibitors has been shown to lower IOP, and angiotensin-induced increase in vascular tone has been implicated as a pathogenetic mechanism in glaucomatous cupping and damage to the optic nerve. The objective of this study was to investigate the association between the deletion polymorphism in the ACE gene and ocular signs of POAG.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0721-832X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
243
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
294-9
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pubmed:meshHeading |
pubmed-meshheading:15864617-Aged,
pubmed-meshheading:15864617-Blood Pressure,
pubmed-meshheading:15864617-Female,
pubmed-meshheading:15864617-Gene Deletion,
pubmed-meshheading:15864617-Genotype,
pubmed-meshheading:15864617-Glaucoma, Open-Angle,
pubmed-meshheading:15864617-Humans,
pubmed-meshheading:15864617-Intraocular Pressure,
pubmed-meshheading:15864617-Male,
pubmed-meshheading:15864617-Middle Aged,
pubmed-meshheading:15864617-Ocular Hypertension,
pubmed-meshheading:15864617-Optic Disk,
pubmed-meshheading:15864617-Optic Nerve Diseases,
pubmed-meshheading:15864617-Peptidyl-Dipeptidase A,
pubmed-meshheading:15864617-Polymerase Chain Reaction,
pubmed-meshheading:15864617-Polymorphism, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Associations between the deletion polymorphism of the angiotensin 1-converting enzyme gene and ocular signs of primary open-angle glaucoma.
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pubmed:affiliation |
Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK. c.bunce@ucl.ac.uk
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pubmed:publicationType |
Journal Article
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