15864395

Source:http://linkedlifedata.com/resource/pubmed/id/15864395

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0001792, umls-concept:C0002395, umls-concept:C0683956, umls-concept:C1704788, umls-concept:C2750110
pubmed:issue	3
pubmed:dateCreated	2005-5-2
pubmed:abstractText	The pattern and rate of cognitive decline in AD patients is far from uniform. In clinical practice, certain patients present episodes of rapid cognitive loss, whereas others deteriorate more progressively. At present time, there is little known about rapid decline in cognitive function in patients with AD, and moreover among older population. The main objective of this review was to elaborate a proposal of definition of rapid cognitive decline in order to facilitate its applicability into ordinary medical practice and to be relevant for clinical-decision making in old patients with AD. After the literature review, our results from longitudinal prospective studies and our clinical practice experience, we propose the following definition of rapid cognitive decline: a four-point or greater loss on the MMSE within six months and the loss of at least one point on the MMSE during the following six months. After ELSA cohort's results, 11% of an AD population of 312 patients were rapid cognitive decliners, complying with our proposed definition. They represent a non-negligible proportion of the population afflicted by AD.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100893366
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:issn	1279-7707
pubmed:author	pubmed-author:Gillette-GuyonnetSS, pubmed-author:REAL.FR group, pubmed-author:SotoM EME, pubmed-author:VellasBB
pubmed:issnType	Print
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	158-61
pubmed:dateRevised	2009-6-26
pubmed:meshHeading	pubmed-meshheading:15864395-Activities of Daily Living, pubmed-meshheading:15864395-Aged, pubmed-meshheading:15864395-Alzheimer Disease, pubmed-meshheading:15864395-Cognition Disorders, pubmed-meshheading:15864395-Humans, pubmed-meshheading:15864395-Risk Factors
pubmed:year	2005
pubmed:articleTitle	Rapid cognitive decline: searching for a definition and predictive factors among elderly with Alzheimer's disease.
pubmed:affiliation	Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire Purpan-Casselardit, Toulouse, France. mariusoto@hotmail.com
pubmed:publicationType	Journal Article, Review, Research Support, Non-U.S. Gov't