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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-5-2
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pubmed:abstractText |
Alpha-2B adrenoceptors (AR) mediate vasoconstriction in the mice. A human alpha-2B AR deletion (D) variant has been associated with loss of short-term agonist-promoted receptor desensitization, which may lead to increased vasoconstriction upon alpha-2 AR activation. This study tested the hypothesis that alpha-2 AR activation will induce enhanced vasoconstriction in carriers of the alpha-2B AR DD genotype, compared to carriers of the II or the DI genotypes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1744-6872
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
357-63
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:15864138-Adrenergic alpha-2 Receptor Agonists,
pubmed-meshheading:15864138-Adrenergic alpha-Agonists,
pubmed-meshheading:15864138-Adult,
pubmed-meshheading:15864138-Aged,
pubmed-meshheading:15864138-Blood Pressure,
pubmed-meshheading:15864138-Dexmedetomidine,
pubmed-meshheading:15864138-Female,
pubmed-meshheading:15864138-Heart Rate,
pubmed-meshheading:15864138-Humans,
pubmed-meshheading:15864138-Male,
pubmed-meshheading:15864138-Middle Aged,
pubmed-meshheading:15864138-Polymorphism, Genetic,
pubmed-meshheading:15864138-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:15864138-Vasoconstriction
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pubmed:year |
2005
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pubmed:articleTitle |
Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction.
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pubmed:affiliation |
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, California 94143-0648, USA. talkep@anesthesia.ucsf.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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