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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0033975,
umls-concept:C0040615,
umls-concept:C0043094,
umls-concept:C0043157,
umls-concept:C0299583,
umls-concept:C0332281,
umls-concept:C0528200,
umls-concept:C0681850,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1882417,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
4
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pubmed:dateCreated |
2005-5-2
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pubmed:abstractText |
Weight gain, leading to further morbidity and poor treatment adherence, is a common consequence of treatment with antipsychotic drugs. Two recent studies in the same cohort of Chinese Han subjects have shown that polymorphisms of the promoter regions of both the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor and the leptin genes, are associated with antipsychotic-induced weight gain over 10 weeks. We have investigated whether these effects remain true in a Caucasian population and following longer term treatment.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antipsychotic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzodiazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/leptin receptor, human,
http://linkedlifedata.com/resource/pubmed/chemical/olanzapine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1744-6872
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
195-200
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15864111-Adult,
pubmed-meshheading:15864111-Affective Disorders, Psychotic,
pubmed-meshheading:15864111-Alleles,
pubmed-meshheading:15864111-Antipsychotic Agents,
pubmed-meshheading:15864111-Benzodiazepines,
pubmed-meshheading:15864111-Body Mass Index,
pubmed-meshheading:15864111-Female,
pubmed-meshheading:15864111-Genetic Variation,
pubmed-meshheading:15864111-Genotype,
pubmed-meshheading:15864111-Humans,
pubmed-meshheading:15864111-Leptin,
pubmed-meshheading:15864111-Male,
pubmed-meshheading:15864111-Models, Genetic,
pubmed-meshheading:15864111-Pharmacogenetics,
pubmed-meshheading:15864111-Polymorphism, Genetic,
pubmed-meshheading:15864111-Promoter Regions, Genetic,
pubmed-meshheading:15864111-Receptor, Serotonin, 5-HT2C,
pubmed-meshheading:15864111-Receptors, Leptin,
pubmed-meshheading:15864111-Schizophrenia,
pubmed-meshheading:15864111-Time Factors,
pubmed-meshheading:15864111-Weight Gain
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pubmed:year |
2005
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pubmed:articleTitle |
Polymorphisms of the 5-HT2C receptor and leptin genes are associated with antipsychotic drug-induced weight gain in Caucasian subjects with a first-episode psychosis.
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pubmed:affiliation |
Division of Psychiatry and Neuroscience, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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