Linked Life Data

15863306

Source:http://linkedlifedata.com/resource/pubmed/id/15863306

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-5-2
pubmed:abstractText
As a part of an ongoing search for new isoniazid-related isonicotinoylhydrazones (ISNEs), 2'-monosubstituted isonicotinohydrazides and cyanoboranes, some analogues belonging to these three series of compounds were further evaluated in an in vitro advanced antimycobacterial screening. The results here reported allowed us to extend their structure-activity relationships. A general correlation emerged between their lipophilicity and effectiveness against intracellular M. tuberculosis. On the whole, the most interesting result of this research was that some hydrazides and ISNEs proved to be more effective antimycobacterial agents than parental isoniazid in a TB-infected macrophage model.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2509-13
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
In vitro advanced antimycobacterial screening of isoniazid-related hydrazones, hydrazides and cyanoboranes: part 14.
pubmed:affiliation
Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, Viale SS. Annunziata, 98168 Messina, Italy. rmaccari@pharma.unime.it
pubmed:publicationType
Journal Article