Linked Life Data

15863302

Source:http://linkedlifedata.com/resource/pubmed/id/15863302

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-5-2
pubmed:abstractText
A number of tetrasubstituted pyrrole derivatives have been synthesized and evaluated for their in vitro antiproliferative activities using the human promyelocytic leukemia cell line HL60. Tetrasubstituted pyrroles are obtained by irradiation of a silica gel absorbed mixture of a conjugated alkynoate and a primary amine. Active compounds exhibited GI50 values in the range 4-45 microM, and only six products showed TGI values within the evaluation range. A structure-activity relationship is also discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2487-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Antiproliferative activity in HL60 cells by tetrasubstituted pyrroles: a structure-activity relationship study.
pubmed:affiliation
Unidad de Investigación, Hospital Universitario NS de Candelaria, Ctra. del Rosario s/n, 38010 Santa Cruz de Tenerife, Spain. jmpadron@ull.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't