| pubmed-article:15863256 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15863256 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:15863256 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15863256 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:15863256 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:15863256 | lifeskim:mentions | umls-concept:C0028746 | lld:lifeskim |
| pubmed-article:15863256 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15863256 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15863256 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:15863256 | pubmed:dateCreated | 2005-5-2 | lld:pubmed |
| pubmed-article:15863256 | pubmed:abstractText | The objective of this study was to investigate the CYP1A1 and CYP1A2 mRNAs and enzyme activities in mouse liver during induction with o-aminoazotoluene (OAT) as well as the capability of the hepatic S9-fraction from OAT-treated mice to induce its own activation to mutagens in the Ames test using S. typhymurium strain TA98. The data obtained indicate that when used at appropriate doses, OAT is a PAH-type inducer of mouse hepatic microsomal monooxygenases, which activity is not less than that of the known inducer 3,4-benzo[alpha]pyrene. In the absence of S9-fraction enzymes no OAT-mediated mutagenicity was observed in the Ames test. In the presence of the S9-fraction from OAT-pretreated mice, OAT induced as high revertant numbers, as it did in the presence of the S9 fraction from the liver of Aroclor 1254-treated mice. Thus, OAT does induce the enzymes of its own mutagenic activation in mouse liver. | lld:pubmed |
| pubmed-article:15863256 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15863256 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15863256 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15863256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15863256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15863256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15863256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15863256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15863256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15863256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15863256 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15863256 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15863256 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15863256 | pubmed:issn | 0300-483X | lld:pubmed |
| pubmed-article:15863256 | pubmed:author | pubmed-author:FilipenkoMaxi... | lld:pubmed |
| pubmed-article:15863256 | pubmed:author | pubmed-author:TimofeevaOlga... | lld:pubmed |
| pubmed-article:15863256 | pubmed:author | pubmed-author:VasyuninaElen... | lld:pubmed |
| pubmed-article:15863256 | pubmed:author | pubmed-author:MikhailovaOlg... | lld:pubmed |
| pubmed-article:15863256 | pubmed:author | pubmed-author:KaledinVasily... | lld:pubmed |
| pubmed-article:15863256 | pubmed:author | pubmed-author:GulyaevaLyudm... | lld:pubmed |
| pubmed-article:15863256 | pubmed:author | pubmed-author:OvchinnikovaL... | lld:pubmed |
| pubmed-article:15863256 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15863256 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15863256 | pubmed:volume | 211 | lld:pubmed |
| pubmed-article:15863256 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15863256 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15863256 | pubmed:pagination | 132-8 | lld:pubmed |
| pubmed-article:15863256 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:15863256 | pubmed:meshHeading | pubmed-meshheading:15863256... | lld:pubmed |
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| pubmed-article:15863256 | pubmed:meshHeading | pubmed-meshheading:15863256... | lld:pubmed |
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| pubmed-article:15863256 | pubmed:meshHeading | pubmed-meshheading:15863256... | lld:pubmed |
| pubmed-article:15863256 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15863256 | pubmed:articleTitle | o-Aminoazotoluene does induce the enzymes of its own mutagenic activation in mouse liver. | lld:pubmed |
| pubmed-article:15863256 | pubmed:affiliation | Laboratory of Molecular Mechanisms of Carcinogenesis, Institute of Molecular Biology and Biophysics, Timakov Street 2, Novosibirsk 630117, Russia. pharmacogenomics@ngs.ru | lld:pubmed |
| pubmed-article:15863256 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15863256 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
