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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-5-2
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pubmed:abstractText |
The objective of this study was to investigate the CYP1A1 and CYP1A2 mRNAs and enzyme activities in mouse liver during induction with o-aminoazotoluene (OAT) as well as the capability of the hepatic S9-fraction from OAT-treated mice to induce its own activation to mutagens in the Ames test using S. typhymurium strain TA98. The data obtained indicate that when used at appropriate doses, OAT is a PAH-type inducer of mouse hepatic microsomal monooxygenases, which activity is not less than that of the known inducer 3,4-benzo[alpha]pyrene. In the absence of S9-fraction enzymes no OAT-mediated mutagenicity was observed in the Ames test. In the presence of the S9-fraction from OAT-pretreated mice, OAT induced as high revertant numbers, as it did in the presence of the S9 fraction from the liver of Aroclor 1254-treated mice. Thus, OAT does induce the enzymes of its own mutagenic activation in mouse liver.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0300-483X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
211
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
132-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15863256-Animals,
pubmed-meshheading:15863256-Benzo(a)pyrene,
pubmed-meshheading:15863256-Biotransformation,
pubmed-meshheading:15863256-Chlorodiphenyl (54% Chlorine),
pubmed-meshheading:15863256-Cytochrome P-450 CYP1A1,
pubmed-meshheading:15863256-Cytochrome P-450 CYP1A2,
pubmed-meshheading:15863256-DNA, Complementary,
pubmed-meshheading:15863256-Enzyme Induction,
pubmed-meshheading:15863256-Hydroxylation,
pubmed-meshheading:15863256-Liver,
pubmed-meshheading:15863256-Male,
pubmed-meshheading:15863256-Mice,
pubmed-meshheading:15863256-Mice, Inbred C57BL,
pubmed-meshheading:15863256-Mutagenicity Tests,
pubmed-meshheading:15863256-Mutagens,
pubmed-meshheading:15863256-RNA,
pubmed-meshheading:15863256-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15863256-Subcellular Fractions,
pubmed-meshheading:15863256-o-Aminoazotoluene
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pubmed:year |
2005
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pubmed:articleTitle |
o-Aminoazotoluene does induce the enzymes of its own mutagenic activation in mouse liver.
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pubmed:affiliation |
Laboratory of Molecular Mechanisms of Carcinogenesis, Institute of Molecular Biology and Biophysics, Timakov Street 2, Novosibirsk 630117, Russia. pharmacogenomics@ngs.ru
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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