Linked Life Data

15863004

Source:http://linkedlifedata.com/resource/pubmed/id/15863004

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2005-5-2
pubmed:abstractText
A number of aminoacyl triesters of squamocin 1, a cytotoxic acetogenin isolated from the seeds of Annona reticulata, have been synthesized in two to three steps from protected (l)-aminoacids and squamocin 1 using standard coupling/deprotection procedures. These semisynthetic analogs were tested on submitochondrial particles (SMP) for their complex I inhibitory activities, and against KB 3-1 cells in vitro. All triesters derivatives exhibited a complete extinction of activity at the enzymatic level, correlated to a reduced though modulated cytotoxicity in comparison with squamocin 1. This activity can apparently be considered as a function of the amphipathy of the analogs, the more amphiphilic ones being the more cytotoxic.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0968-0896
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3773-81
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Semisynthesis and biological activity of aminoacyl triesters of squamocin, an annonaceous acetogenin.
pubmed:affiliation
Laboratoire de Pharmacognosie (BioCIS, UMR 8076 CNRS), Faculté de Pharmacie, rue J.B. Clément, 92296 Châtenay-Malabry Cedex, France.
pubmed:publicationType
Journal Article