Linked Life Data

15862973

Source:http://linkedlifedata.com/resource/pubmed/id/15862973

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2005-5-2
pubmed:abstractText
In this study we examined and compared the 5' flanking regions (promoter regions) of human and murine 17beta-hydroxysteroid dehydrogenase type 7 genes (HSD17B7). In 1998, this enzyme was described to convert estrone to biologically more active estradiol. However, in 2001, it was predicted to be involved in cholesterol biosynthesis. To elucidate the mechanism governing HSD17B7 expression and its function, we analyzed the promoter regions by bioinformatic and experimental approaches. Our study provides new insights to the transcriptional regulation of HSD17B7 and further hints to its involvement in cholesterol biosynthesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0960-0760
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
259-61
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7.
pubmed:affiliation
GSF-National Research Center for Environment and Health, Institute of Experimental Genetics, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't