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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-5-2
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pubmed:abstractText |
Gentisic acid, an aspirin metabolite, has an antioxidant effect, although its detailed mechanism remains elusive. The present study was designed to determine whether it inhibits low-density lipoprotein (LDL) oxidation and the formation of lipid hydroperoxides in human plasma. The susceptibility of LDL oxidative modification was investigated by a method using 2,2'-azobis or Cu2+. To study the effect of gentisic acid on free radical-induced damage to plasma lipids, cholesterol ester hydroperoxides generated by incubating human fresh plasma with Cu2+ and gentisic acid was analyzed. Gentisic acid inhibited LDL oxidation in a concentration-dependent manner. It significantly inhibited the formation of cholesterol ester hydroperoxides in plasma, and was consumed after the depletion of ascorbic acid and reduced form of coenzyme Q-10 (CoQH2-10), whereas concentrations of other antioxidants remained unchanged. Gentisic acid had a potent free radical scavenging activity with a minimal chelating effect. The potent antioxidant property of gentisic acid may partly account for the anti-atherogenic effects of aspirin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,5-dihydroxybenzoic acid,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Azo Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Chelating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Ferrous Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radical Scavengers,
http://linkedlifedata.com/resource/pubmed/chemical/Gentisates,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid Peroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/V 70,
http://linkedlifedata.com/resource/pubmed/chemical/ferrous sulfate
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
513
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15862799-Antioxidants,
pubmed-meshheading:15862799-Aspirin,
pubmed-meshheading:15862799-Azo Compounds,
pubmed-meshheading:15862799-Cell Line,
pubmed-meshheading:15862799-Chelating Agents,
pubmed-meshheading:15862799-Cholesterol Esters,
pubmed-meshheading:15862799-Dose-Response Relationship, Drug,
pubmed-meshheading:15862799-Ferrous Compounds,
pubmed-meshheading:15862799-Free Radical Scavengers,
pubmed-meshheading:15862799-Gentisates,
pubmed-meshheading:15862799-Humans,
pubmed-meshheading:15862799-Lipid Peroxides,
pubmed-meshheading:15862799-Lipoproteins, LDL,
pubmed-meshheading:15862799-Nitriles,
pubmed-meshheading:15862799-Oxidation-Reduction
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pubmed:year |
2005
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pubmed:articleTitle |
Gentisic acid, an aspirin metabolite, inhibits oxidation of low-density lipoprotein and the formation of cholesterol ester hydroperoxides in human plasma.
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pubmed:affiliation |
Department of Internal Medicine, Kudanzaka Hospital, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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