| pubmed-article:15860590 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15860590 | lifeskim:mentions | umls-concept:C0369497 | lld:lifeskim |
| pubmed-article:15860590 | lifeskim:mentions | umls-concept:C0373916 | lld:lifeskim |
| pubmed-article:15860590 | lifeskim:mentions | umls-concept:C0007188 | lld:lifeskim |
| pubmed-article:15860590 | pubmed:issue | 5730 | lld:pubmed |
| pubmed-article:15860590 | pubmed:dateCreated | 2005-6-24 | lld:pubmed |
| pubmed-article:15860590 | pubmed:abstractText | The design of a human immunodeficiency virus-1 (HIV-1) immunogen that can induce broadly reactive neutralizing antibodies is a major goal of HIV-1 vaccine development. Although rare human monoclonal antibodies (mAbs) exist that broadly neutralize HIV-1, HIV-1 envelope immunogens do not induce these antibody specificities. Here we demonstrate that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin. Thus, current HIV-1 vaccines may not induce these types of antibodies because of autoantigen mimicry of the conserved membrane-proximal epitopes of the virus. These results may have important implications for generating effective neutralizing antibody responses by using HIV-1 vaccines. | lld:pubmed |
| pubmed-article:15860590 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15860590 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15860590 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15860590 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15860590 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15860590 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15860590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15860590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15860590 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15860590 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15860590 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15860590 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:LiaoHua-XinHX | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:HaynesBarton... | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:StaatsHerman... | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:RobinsonJames... | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:OrtelThomas... | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:StieglerGabri... | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:AlamS MunirSM | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:ScearceRichar... | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:St ClairE... | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:KunertRenateR | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:KatingerHerma... | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:FlemingJudith... | lld:pubmed |
| pubmed-article:15860590 | pubmed:author | pubmed-author:PlonkKellyK | lld:pubmed |
| pubmed-article:15860590 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15860590 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:15860590 | pubmed:volume | 308 | lld:pubmed |
| pubmed-article:15860590 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15860590 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15860590 | pubmed:pagination | 1906-8 | lld:pubmed |
| pubmed-article:15860590 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15860590 | pubmed:meshHeading | pubmed-meshheading:15860590... | lld:pubmed |
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| pubmed-article:15860590 | pubmed:meshHeading | pubmed-meshheading:15860590... | lld:pubmed |
| pubmed-article:15860590 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15860590 | pubmed:articleTitle | Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. | lld:pubmed |
| pubmed-article:15860590 | pubmed:affiliation | Duke University School of Medicine, Durham, NC 27710, USA. hayne002@mc.duke.edu | lld:pubmed |
| pubmed-article:15860590 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15860590 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15860590 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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