Linked Life Data

15858352

Source:http://linkedlifedata.com/resource/pubmed/id/15858352

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-4-28
pubmed:abstractText
Effects of hindlimb suspension or exposure to 2-G between postnatal day 4 and month 3 and of 3-month recovery at 1-G environment on the characteristics of rat hindlimb muscles were studied. Pronounced growth inhibition was induced by unloading, but not by 2-G loading. It is suggested that the development and/or differentiation of soleus muscle fibers are closely associated with gravitational loading. The data indicated that gravitational unloading during postnatal development inhibits the myonuclear accretion in accordance with subnormal numbers of both mitotic active and quiescent satellite cells. Even though the fiber formation and longitudinal fiber growth were not influenced, cross-sectional growth of muscle fibers was also inhibited in association with lesser myonuclear domain and DNA content per unit volume of myonucleus. Unloading-related inhibition was generally normalized following the recovery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
S
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0914-9201
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NASA
pubmed:authorsComplete
Y
pubmed:pagination
124-5
pubmed:dateRevised
2009-6-4
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Role of gravity in mammalian development: effects of hypergravity and/or microgravity on the development of skeletal muscles.
pubmed:affiliation
Sch. Health Sport Sci, Osaka Univ.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't