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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-4-28
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pubmed:abstractText |
Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain (MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors, mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding protein 2 (MeCP2) have been linked to the human mental retardation disorder Rett syndrome, suggesting an important role for methyl-CpG binding proteins in brain development and function. This mini-review summarizes the recent advances in studying the diverse functions of MeCP2 as a prototype for other methyl-CpG binding proteins in the development and function of the vertebrate nervous system.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1001-0602
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
255-61
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15857580-Animals,
pubmed-meshheading:15857580-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:15857580-CpG Islands,
pubmed-meshheading:15857580-DNA Methylation,
pubmed-meshheading:15857580-DNA-Binding Proteins,
pubmed-meshheading:15857580-Humans,
pubmed-meshheading:15857580-Methyl-CpG-Binding Protein 2,
pubmed-meshheading:15857580-Mutation,
pubmed-meshheading:15857580-Nervous System,
pubmed-meshheading:15857580-RNA, Messenger,
pubmed-meshheading:15857580-Repressor Proteins
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pubmed:year |
2005
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pubmed:articleTitle |
Methyl-CpG binding proteins in the nervous system.
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pubmed:affiliation |
Department of Human Genetics and Interdepartmental Program of Neuroscience, David Geffen School of Medicine, University of California at Los Angeles, 90095-7088, USA. gfan@mednet.ucla.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, N.I.H., Extramural
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