Source:http://linkedlifedata.com/resource/pubmed/id/15856411
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2005-4-27
|
| pubmed:abstractText |
One new diterpene, 8(14),15-sandaracopimaradiene-2alpha,3beta,18-triol (1), two new phenylpropane derivatives, i.e., (E)-methyl 2-(3,4-methylene-dioxyphenyl)-3-methoxypropenoate (2) and (E)-2-(3,4-methylene-dioxyphenyl)-3-methoxypropenoic acid (3), and two known diterpenes, ent-8(14),15-sandaracopimaradiene-2alpha,18-diol (4) and 8(14),15-sandaracopimaradiene-2alpha,18,19-triol (5), were isolated from the heartwoods and barks of Amentotaxus formosana, respectively. The anti-inflammatory activity of the diterpenes 1, 4, and 5 was assessed in vitro by determining their inhibitory effects on the chemical mediators released from mast cells, neutrophils, macrophages, and microglial cells. Compounds 1, 4, and 5 showed significant concentration-dependent inhibitory effects on the release of beta-glucuronidase from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B (fMLP/CB) with IC50 values of 5.5 +/- 1.8, 8.4 +/- 2.9 and 19.2 +/- 3.3 microM, respectively. Compounds 1 and 5 also showed significant concentration-dependent inhibitory effects on superoxide anion generation in rat neutrophils stimulated with fMLP/CB and phorbol 12-myristate 13-acetate (PMA) with IC50 values of 12.6 +/- 1.2 and 9.4 +/- 1.7, and 10.7 +/- 3.3 and 12.9 +/- 0.9 microM, respectively.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0032-0943
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
344-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15856411-Animals,
pubmed-meshheading:15856411-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:15856411-Diterpenes,
pubmed-meshheading:15856411-Dose-Response Relationship, Drug,
pubmed-meshheading:15856411-Hydrocarbons, Aromatic,
pubmed-meshheading:15856411-Inhibitory Concentration 50,
pubmed-meshheading:15856411-Macrophages,
pubmed-meshheading:15856411-Mast Cells,
pubmed-meshheading:15856411-Mice,
pubmed-meshheading:15856411-Neuroglia,
pubmed-meshheading:15856411-Neutrophils,
pubmed-meshheading:15856411-Phytotherapy,
pubmed-meshheading:15856411-Plant Bark,
pubmed-meshheading:15856411-Plant Extracts,
pubmed-meshheading:15856411-Rats,
pubmed-meshheading:15856411-Rats, Sprague-Dawley,
pubmed-meshheading:15856411-Taxaceae,
pubmed-meshheading:15856411-Wood
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
New phenylpropane and anti-inflammatory diterpene derivatives from Amentotaxus formosana.
|
| pubmed:affiliation |
School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|