Linked Life Data

15856082

Source:http://linkedlifedata.com/resource/pubmed/id/15856082

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-9-19
pubmed:abstractText
Disruption of the dopamine (DA) transporter (Dat1) gene in mice leads to a 50% reduction or complete elimination of Dat1 expression in striatum of respective heterozygous (HZ) and knockout (KO) mice. Compared to wild-type (WT) controls, extracellular DA is increased approximately two- and five-fold in the mutants. Although open field (OF) activity is similar for WT and HZ animals, it is enhanced for KO mice. The purpose of the present investigations was to study spontaneously emitted behaviors and to determine the behavioral and neurochemical mechanisms that may contribute to the hyperactivity of KO animals. Heterozygotes are less anxious than other genotypes and they engage in novelty-seeking behaviors that include increased time spent in the center of the OF, enhanced investigation of objects, and augmented free exploration of a novel environment. By comparison, KO mice display neophobia when initially exposed to novel conditions. Over time the anxiety-like response habituates and behaviors become activated and stereotyped; these responses are unrelated to exploration or novelty seeking. No alterations in extracellular DA levels or tissue contents from several brain regions are detected at the time of stereotypic activation of KO mice. By contrast, this behavior is accompanied by changes in serotonin metabolism in basal ganglia. This feature may contribute to the behavioral inflexibility of KO mice in different experimental contexts. Collectively, these findings suggest that disruption of the Dat1 gene in mice leads to two different phenotypes; one related to anxiety-reducing and novelty seeking, while the other has some homology to disorders with a stereotypical-perseverative spectrum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0893-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1818-31
pubmed:dateRevised
2011-5-18
pubmed:meshHeading
pubmed-meshheading:15856082-Animals, pubmed-meshheading:15856082-Anxiety, pubmed-meshheading:15856082-Behavior, Animal, pubmed-meshheading:15856082-Biogenic Monoamines, pubmed-meshheading:15856082-Brain Chemistry, pubmed-meshheading:15856082-Chi-Square Distribution, pubmed-meshheading:15856082-Diazepam, pubmed-meshheading:15856082-Dopamine Antagonists, pubmed-meshheading:15856082-Dopamine Plasma Membrane Transport Proteins, pubmed-meshheading:15856082-Exploratory Behavior, pubmed-meshheading:15856082-GABA Modulators, pubmed-meshheading:15856082-Haloperidol, pubmed-meshheading:15856082-Heterozygote, pubmed-meshheading:15856082-Hydroxyindoleacetic Acid, pubmed-meshheading:15856082-Male, pubmed-meshheading:15856082-Maze Learning, pubmed-meshheading:15856082-Mice, pubmed-meshheading:15856082-Mice, Inbred C57BL, pubmed-meshheading:15856082-Mice, Knockout, pubmed-meshheading:15856082-Microdialysis, pubmed-meshheading:15856082-Motor Activity, pubmed-meshheading:15856082-Stereotyped Behavior, pubmed-meshheading:15856082-Time Factors
pubmed:year
2005
pubmed:articleTitle
Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene.
pubmed:affiliation
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't