Phosphoinositide 3-kinase (PI3K) is required for murine adipocyte differentiation. However, a recent report concluded that PI3K was not involved in the differentiation of human preadipocytes into adipocytes. We have re-examined the role of PI3K in human preadipocyte differentiation, enrolling more patients and using more adipogenic indices.
Department of Medicine and of Biochemistry, Microbiology and Immunology, Ottawa Health Research Institute, Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.
