Linked Life Data

15850084

Source:http://linkedlifedata.com/resource/pubmed/id/15850084

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-4-26
pubmed:abstractText
The specific objectives of this investigation were: (1) to evaluate the effect of estrogen on SiHa cervical cells delivered by TCPL delivery system versus conventional administration as a model for cervical cancer intervention and (2) to determine the estrogen dose effect on proliferation of these cells in culture. Estrogen was delivered for three time periods, 24, 48, and 72 hours both by conventional administration (direct administration) and drug delivery system using TCPL ceramic capsules. Three dosages of estrogen were selected (2, 10, and 100 pg/mL). Ceramic capsules were prepared using standard procedures (release profile 2, 10 or 100 pg/mL). Capsules were gas sterilized prior to being placed in the wells with cells. Data collected from this study indicated that, regardless of the route of administration, estrogen exposure did not induce major cellular injury at the 24 and 48 hour time period. Initially, there were various responses to estrogen among all groups compared to control. At 72 hours phase all experimental groups induced greater proliferation rate in the conventional delivery than in the groups exposed to sustained estrogen delivery. Low and medium doses conventionally added to the cells resulted in a decrease in cell number at 48 hours phase compared to the initial response at the 24 hours phase. With medium and high sustained delivery of estrogen rates, the data revealed that proliferation rate is directly proportional to duration of delivery compared to conventional means. The data suggest that the route of administration of estrogen is an instrumental tool in the prognosis of cervical cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0067-8856
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
68-73
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
The role of route of estrogen adminstration on the proliferation of SiHa cells in culture.
pubmed:affiliation
University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
pubmed:publicationType
Journal Article, Comparative Study, Evaluation Studies