Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-4-25
pubmed:abstractText
Long-term exposure to extremely low frequency magnetic fields (ELF-MFs) may be a risk factor for human cancer. One mechanism through which ELF-MFs could influence neoplastic development is the deletion/mutation of cancer-related genes. Cellular proliferation follows an orderly progression through the cell cycle, which is governed by different cyclins and cyclin-dependent kinase inhibitors (CDKIs). The putative tumor suppressor gene p18(INK4C) encodes a specific inhibitor of cyclin D-cyclin-dependent kinase 4 inhibitor complexes having an important role in cell-cyclin regulation. It has been found to be deleted/mutated in a variety of human cancers. Therefore, this study is to investigate whether or not long-term extremely low frequency electromagnetic field exposure may be a risk factor for human cancer due to the gene p18(INK4C) deletion/mutation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0188-4409
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
120-3
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15847943-Adult, pubmed-meshheading:15847943-Cell Cycle Proteins, pubmed-meshheading:15847943-Cyclin-Dependent Kinase 4, pubmed-meshheading:15847943-Cyclin-Dependent Kinase Inhibitor p18, pubmed-meshheading:15847943-Cyclin-Dependent Kinases, pubmed-meshheading:15847943-Electromagnetic Fields, pubmed-meshheading:15847943-Humans, pubmed-meshheading:15847943-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:15847943-Male, pubmed-meshheading:15847943-Neoplasms, pubmed-meshheading:15847943-Occupational Exposure, pubmed-meshheading:15847943-Occupations, pubmed-meshheading:15847943-Point Mutation, pubmed-meshheading:15847943-Polymerase Chain Reaction, pubmed-meshheading:15847943-Polymorphism, Genetic, pubmed-meshheading:15847943-Polymorphism, Single-Stranded Conformational, pubmed-meshheading:15847943-Power Plants, pubmed-meshheading:15847943-Proto-Oncogene Proteins, pubmed-meshheading:15847943-Risk Factors, pubmed-meshheading:15847943-Tumor Suppressor Proteins
pubmed:articleTitle
Lack of effect of extremely low frequency electromagnetic fields on cyclin-dependent kinase 4 inhibitor gene p18(INK4C) in electric energy workers.
pubmed:affiliation
Department of Biophysics, Faculty of Medicine, University of Mersin, Mersin, Turkey. nerdal@mersin.edu.tr
pubmed:publicationType
Journal Article