rdf:type |
|
lifeskim:mentions |
umls-concept:C0013790,
umls-concept:C0013835,
umls-concept:C0017337,
umls-concept:C0205251,
umls-concept:C0246957,
umls-concept:C0292198,
umls-concept:C0376249,
umls-concept:C1280500,
umls-concept:C1332738,
umls-concept:C1442080,
umls-concept:C1527116,
umls-concept:C1999216
|
pubmed:issue |
2
|
pubmed:dateCreated |
2005-4-25
|
pubmed:abstractText |
Long-term exposure to extremely low frequency magnetic fields (ELF-MFs) may be a risk factor for human cancer. One mechanism through which ELF-MFs could influence neoplastic development is the deletion/mutation of cancer-related genes. Cellular proliferation follows an orderly progression through the cell cycle, which is governed by different cyclins and cyclin-dependent kinase inhibitors (CDKIs). The putative tumor suppressor gene p18(INK4C) encodes a specific inhibitor of cyclin D-cyclin-dependent kinase 4 inhibitor complexes having an important role in cell-cyclin regulation. It has been found to be deleted/mutated in a variety of human cancers. Therefore, this study is to investigate whether or not long-term extremely low frequency electromagnetic field exposure may be a risk factor for human cancer due to the gene p18(INK4C) deletion/mutation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDK4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CDKN2C protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/protein kinase modulator
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0188-4409
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
36
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
120-3
|
pubmed:dateRevised |
2009-11-19
|
pubmed:meshHeading |
pubmed-meshheading:15847943-Adult,
pubmed-meshheading:15847943-Cell Cycle Proteins,
pubmed-meshheading:15847943-Cyclin-Dependent Kinase 4,
pubmed-meshheading:15847943-Cyclin-Dependent Kinase Inhibitor p18,
pubmed-meshheading:15847943-Cyclin-Dependent Kinases,
pubmed-meshheading:15847943-Electromagnetic Fields,
pubmed-meshheading:15847943-Humans,
pubmed-meshheading:15847943-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15847943-Male,
pubmed-meshheading:15847943-Neoplasms,
pubmed-meshheading:15847943-Occupational Exposure,
pubmed-meshheading:15847943-Occupations,
pubmed-meshheading:15847943-Point Mutation,
pubmed-meshheading:15847943-Polymerase Chain Reaction,
pubmed-meshheading:15847943-Polymorphism, Genetic,
pubmed-meshheading:15847943-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:15847943-Power Plants,
pubmed-meshheading:15847943-Proto-Oncogene Proteins,
pubmed-meshheading:15847943-Risk Factors,
pubmed-meshheading:15847943-Tumor Suppressor Proteins
|
pubmed:articleTitle |
Lack of effect of extremely low frequency electromagnetic fields on cyclin-dependent kinase 4 inhibitor gene p18(INK4C) in electric energy workers.
|
pubmed:affiliation |
Department of Biophysics, Faculty of Medicine, University of Mersin, Mersin, Turkey. nerdal@mersin.edu.tr
|
pubmed:publicationType |
Journal Article
|