15846474

Source:http://linkedlifedata.com/resource/pubmed/id/15846474

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0020433, umls-concept:C0034693, umls-concept:C0034721, umls-concept:C0086418, umls-concept:C0087111, umls-concept:C1412077
pubmed:issue	4
pubmed:dateCreated	2005-4-22
pubmed:abstractText	Multidrug resistance-associated protein 2 (MRP2/ABCC2) is predominantly expressed in the liver canalicular membrane and plays an important role in the biliary excretion of organic anions including glucuronide and glutathione conjugates. The purpose of this study is to construct a new evaluation system for human MRP2 by expressing human MRP2 in Eisai hyperbilirubinemic rat (EHBR) liver, the rat Mrp2 function of which is hereditarily defective.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8406521
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Bilirubin, http://linkedlifedata.com/resource/pubmed/chemical/Estradiol, http://linkedlifedata.com/resource/pubmed/chemical/Glutathione, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Multidrug Resistance-Associated..., http://linkedlifedata.com/resource/pubmed/chemical/S-(2,4-dinitrophenyl)glutathione, http://linkedlifedata.com/resource/pubmed/chemical/Sulfobromophthalein, http://linkedlifedata.com/resource/pubmed/chemical/dibromosulphthalein, http://linkedlifedata.com/resource/pubmed/chemical/estradiol-17 beta-glucuronide, http://linkedlifedata.com/resource/pubmed/chemical/multidrug resistance-associated...
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0724-8741
pubmed:author	pubmed-author:HirouchiMasakazuM, pubmed-author:SugiyamaYuichiY, pubmed-author:SuzukiHiroshiH
pubmed:issnType	Print
pubmed:volume	22
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	661-6
pubmed:dateRevised	2006-4-21
pubmed:meshHeading	pubmed-meshheading:15846474-Adenoviridae, pubmed-meshheading:15846474-Animals, pubmed-meshheading:15846474-Bile, pubmed-meshheading:15846474-Bile Canaliculi, pubmed-meshheading:15846474-Bilirubin, pubmed-meshheading:15846474-Biological Transport, pubmed-meshheading:15846474-Estradiol, pubmed-meshheading:15846474-Gene Expression, pubmed-meshheading:15846474-Gene Therapy, pubmed-meshheading:15846474-Genetic Vectors, pubmed-meshheading:15846474-Glutathione, pubmed-meshheading:15846474-Humans, pubmed-meshheading:15846474-Hyperbilirubinemia, pubmed-meshheading:15846474-Liver, pubmed-meshheading:15846474-Membrane Transport Proteins, pubmed-meshheading:15846474-Multidrug Resistance-Associated Proteins, pubmed-meshheading:15846474-Rats, pubmed-meshheading:15846474-Rats, Sprague-Dawley, pubmed-meshheading:15846474-Sulfobromophthalein, pubmed-meshheading:15846474-Transport Vesicles
pubmed:year	2005
pubmed:articleTitle	Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene.
pubmed:affiliation	School of Pharmaceutical Sciences, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
pubmed:publicationType	Journal Article