|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005098,
umls-concept:C0006104,
umls-concept:C0013030,
umls-concept:C0031809,
umls-concept:C0201734,
umls-concept:C0206056,
umls-concept:C0220825,
umls-concept:C0243071,
umls-concept:C0441889,
umls-concept:C0442111,
umls-concept:C0870071,
umls-concept:C1142936,
umls-concept:C1620209,
umls-concept:C1709518
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2005-4-22
|
|
pubmed:abstractText |
The benztropine (BZT) analogues bind with high affinity to the dopamine transporter (DAT) and demonstrate a behavioral and pharmacokinetic profile unlike that of cocaine. The development of a predictive pharmacokinetic/pharmacodynamic (PK/PD) model to characterize the concentration-effect relationship between the BZT analogues and brain dopamine (DA) levels is an important step in the evaluation of these compounds as potential cocaine abuse pharmacotherapies. Hence, the objective of this study was to mathematically characterize the PD of BZT analogues and cocaine, using appropriate PK/PD models.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0724-8741
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
603-12
|
|
pubmed:meshHeading |
pubmed-meshheading:15846468-Animals,
pubmed-meshheading:15846468-Benztropine,
pubmed-meshheading:15846468-Brain,
pubmed-meshheading:15846468-Cocaine,
pubmed-meshheading:15846468-Dopamine,
pubmed-meshheading:15846468-Dopamine Uptake Inhibitors,
pubmed-meshheading:15846468-Extracellular Fluid,
pubmed-meshheading:15846468-Male,
pubmed-meshheading:15846468-Microdialysis,
pubmed-meshheading:15846468-Models, Biological,
pubmed-meshheading:15846468-Nucleus Accumbens,
pubmed-meshheading:15846468-Rats,
pubmed-meshheading:15846468-Rats, Sprague-Dawley
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Pharmacodynamic assessment of the benztropine analogues AHN-1055 and AHN-2005 using intracerebral microdialysis to evaluate brain dopamine levels and pharmacokinetic/pharmacodynamic modeling.
|
|
pubmed:affiliation |
Pharmacokinetics Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA.
|
|
pubmed:publicationType |
Journal Article
|
