Linked Life Data

15846065

Source:http://linkedlifedata.com/resource/pubmed/id/15846065

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-6-22
pubmed:abstractText
The fidelity of chromosome segregation during cell division is critical to maintain genomic stability and to prevent cancer and birth defects. A key set of kinases that regulates this process has been identified and characterized over the last few years, including the Aurora, Polo and Nek families. Recently we proposed that a little-studied kinase known as haspin is a new member of this important group. During mitosis haspin is phosphorylated, associates with the chromosomes, centrosomes and spindle, and is responsible for phosphorylation of histone H3 at threonine-3. Depletion of haspin using RNA interference prevents normal alignment of chromosomes at metaphase, suggesting that haspin plays a crucial role in chromosome segregation. Here we discuss possible mechanisms of haspin action and the function of histone phosphorylation in mitosis. We also outline some of the questions raised by these new findings and consider what role haspin might play in cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1551-4005
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
665-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Haspin: a mitotic histone kinase required for metaphase chromosome alignment.
pubmed:affiliation
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston Massachusetts 02115, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural