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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-4-22
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pubmed:abstractText |
An immunization campaign with meningococcal ACYW135 polysaccharide vaccine was conducted in 2003 by the Saudi Arabian Ministry of Health and included a study to evaluate the immune responses in children under 5 years of age in the Al Qassim region of Saudi Arabia. Children who were >/=24 months old were given one dose of tetravalent polysaccharide vaccine, while younger children were given two doses with an interval of 2 to 3 months. Blood samples were collected prevaccination and 1 month after the second dose for children younger than 24 months old and 1 month after the single dose for older children. Serogroup-specific antibody responses were determined by serum bactericidal antibody (SBA) assays and a tetraplex immunoglobulin G (IgG) bead assay. Significant increases in the proportions of individuals who were >/=24 months old with SBA titers of >/=8 were observed pre- to postvaccination for all serogroups. Age-dependent increases in the percentage of individuals with SBA titers of >/=8 1 month postvaccination were observed for each serogroup. Age-dependent increases in postvaccination IgG levels were observed for serogroup A (menA), serogroup W135 (menW), and serogroup Y (menY) but not for serogroup C (menC). Two doses of tetravalent polysaccharide vaccine in individuals who were </=18 months old were poorly immunogenic for menC, menW, and menY. However, for menA, 42% of the children who were 18 months old were putatively protected with SBA titers of >/=8. A high percentage of subjects who were >/=2 years of age were putatively protected for menA; a similar level was observed for menY for children who were 4 years of age but not for younger children. However, for menC and menW poor levels of putative protection were still evident at 4 years of age.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-10767611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-11176810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-11179328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-11191548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-11731951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-11880446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-1202084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-12023765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-12037943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-12358061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-12385146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-12559785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-12965904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-14710273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-14715537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-14715549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-15013975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-15365005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-3097160,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-3933203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-4421873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-4977280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-7697519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-9067649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/15845499-9832000
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2932-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15845499-Antibodies, Bacterial,
pubmed-meshheading:15845499-Blood Bactericidal Activity,
pubmed-meshheading:15845499-Child, Preschool,
pubmed-meshheading:15845499-Humans,
pubmed-meshheading:15845499-Immunoglobulin G,
pubmed-meshheading:15845499-Infant,
pubmed-meshheading:15845499-Meningococcal Infections,
pubmed-meshheading:15845499-Meningococcal Vaccines,
pubmed-meshheading:15845499-Neisseria meningitidis,
pubmed-meshheading:15845499-Polysaccharides, Bacterial,
pubmed-meshheading:15845499-Saudi Arabia,
pubmed-meshheading:15845499-Serotyping,
pubmed-meshheading:15845499-Vaccination,
pubmed-meshheading:15845499-Vaccines, Conjugate
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pubmed:year |
2005
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pubmed:articleTitle |
Serologic responses to ACYW135 polysaccharide meningococcal vaccine in Saudi children under 5 years of age.
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pubmed:affiliation |
Meningococcal Reference Unit, HPA North West Laboratory, Manchester Royal Infirmary, Manchester, United Kingdom.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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